Target List
Induction of Apoptosis
Death Domain Receptors
Cradd, Fadd, Tnf, Tnfrsf10b (Dr5)
DNA Damage & Repair
Cidea, Cideb, Trp53 (p53), Trp63 (Tp73l), Trp73
Extracellular Apoptotic Signals
Cflar (Casper), Dapk1
Other Pro-Apoptotic Genes
Bad, Bak1, Bax, Bcl10, Bcl2l11, Bid, Bnip3, Bnip3l, Bok, Casp1 (Ice), Casp12, Casp14, Casp2, Casp3, Casp4, Casp6, Casp8 (Flice), Cd70, Dffa, Dffb, Diablo (Smac), Fas, Fasl, Mapk1 (Erk2), Nod1, Pycard (Tms1, Asc), Tnfsf10 (Trail), Trp53bp2, Traf3
Anti-Apoptotic
Akt1, Api5, Atf5, Bag1, Bag3, Bax, Bcl2, Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Bcl2l10, Bcl2l2, Birc3 (cIAP1, cIAP2), Birc5, Bnip2, Bnip3, Bnip3l, Cd40lg, Cflar (Casper), Dad1, Dapk1, Fas, Igf1r, Il10, Lhx4, Mcl1, Naip1 (Birc1), Naip2, Nfkb1, Nme5, Nol3, Polb, Prdx2, Tnf, Trp63 (Tp73l), Xiap
Regulation of Apoptosis
Negative Regulation of Apoptosis
Bag1, Bag3, Bcl10, Bcl2, Bcl2a1a (Bfl-1, A1), Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Bcl2l10, Bcl2l2, Birc2 (cIAP1, cIAP2), Birc3 (cIAP1, cIAP2), Bnip2, Bnip3, Bnip3l, Casp3, Cd40lg, Cflar (Casper), Cidea, Dapk1, Dffa, Fas, Mcl1, Nol3, Trp53 (p53), Trp73, Xiap
Positive Regulation of Apoptosis
Abl1, Akt1, Anxa5, Bad, Bak1, Bax, Bcl2l11, Bid, Bnip3, Bnip3l, Card10, Casp1 (Ice), Casp14, Casp2, Casp4, Casp6, Casp8 (Flice), Cd40, Cd70, Cideb, Cradd, Fadd, Fasl, Gadd45a, Ltbr, Nod1, Pycard (Tms1, Asc), Tnf, Tnfrsf10b (Dr5), Tnfsf10 (Trail), Tnfsf12 (Apo3l), Trp53 (p53), Trp53bp2, Traf1, Traf2, Traf3
Death Domain Receptors
Cradd, Dapk1, Fadd, Nfkb1, Ripk1, Tnfrsf10b (Dr5), Tnfrsf11b (Opg), Tnfrsf1a (Tnfr1)
Caspases & Regulators
Caspases
Casp1 (Ice), Casp12, Casp14, Casp2, Casp3, Casp4, Casp6, Casp7, Casp8 (Flice), Casp9, Cflar (Casper), Cradd, Pycard (Tms1, Asc)
Caspase Activation
Aifm1, Apaf1, Bax, Bcl2l10, Casp1 (Ice), Casp9, Nod1, Pycard (Tms1, Asc), Tnfrsf10b (Dr5), Trp53 (p53)
Caspase Inhibition
Birc5, Xiap