Icos Gene Summary [Mouse]
Predicted to be involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Located in external side of plasma membrane. Used to study common variable immunodeficiency. Human ortholog(s) of this gene implicated in celiac disease; common variable immunodeficiency 1; and immunoglobulin alpha deficiency. Orthologous to human ICOS (inducible T cell costimulator). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Icos |
| Official Name | inducible T cell co-stimulator [Source:MGI Symbol;Acc:MGI:1858745] |
| Ensembl ID | ENSMUSG00000026009 |
| Bio databases IDs | |
| Aliases | inducible T cell co-stimulator |
| Synonyms | AILIM, CCLP, CD278, CRP-1, CVID1, H4, inducible T-cell co-stimulator, LOC100048841, Ly115 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Icos often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PI3K binding domain
- extracellular domain
- signaling receptor activity
- costimulatory domain
- YMFM Src homology 2 domain-binding motif
- immunoglobulin domain
- protein binding
- Src-homology 2 binding domain
- ICOS V-set domain
- phosphorylation site
- cytoplasmic domain
- immunoglobulin-like protein domain
- intracellular domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Icos gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- infection
- hyperplasia
- rheumatoid arthritis
- systemic lupus erythematosus
- insulitis
- experimental autoimmune myositis
- splenomegaly
- tumorigenesis
phenotypes
- short tibia
- abnormal B cell number
- abnormal B cell physiology
- abnormal B cell selection
- abnormal CD4-positive alpha-beta T cell physiology
- abnormal NK cell physiology
- abnormal Peyer's patch germinal center morphology
- abnormal T cell differentiation
- abnormal T cell physiology
- abnormal T-helper 2 physiology
- abnormal class switch recombination
- abnormal cytokine secretion
- abnormal immune system physiology
- abnormal immunoglobulin level
- abnormal interferon level
- abnormal interleukin level
- abnormal interleukin secretion
- abnormal leukocyte cell number
- abnormal memory B cell number
- abnormal response to infection
- abnormal small intestine morphology
- abnormal spleen germinal center morphology
- abnormal spleen morphology
- decreased CD4-positive alpha beta T cell number
- decreased IgA level
- decreased IgE level
- decreased IgG level
- decreased IgG1 level
- decreased IgG2a level
- decreased IgG2b level
- decreased IgG2c level
- decreased T cell number
- decreased T cell proliferation
- decreased anti-insulin autoantibody level
- decreased autoantibody level
- decreased circulating interferon-gamma level
- decreased circulating interleukin-4 level
- decreased germinal center B cell number
- decreased interferon-gamma secretion
- decreased interleukin-21 secretion
- decreased interleukin-4 secretion
- decreased interleukin-5 secretion
- decreased pancreatic islet number
- decreased plasma cell number
- decreased spleen germinal center number
- decreased spleen germinal center size
- decreased susceptibility to autoimmune diabetes
- increased IgG3 level
- increased plasma cell number
- increased susceptibility to experimental autoimmune encephalomyelitis
- insulitis
- small Peyer's patches
- small lymph nodes
role in cell
- maturation
- formation
- formation in
- expression in
- accumulation
- survival
- growth
- differentiation
- apoptosis
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- Nucleus
- immunological synapses
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Icos gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- T cell costimulation
- T cell tolerance induction
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding