ICOS
ICOS Gene Summary
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ICOS |
| Official Name | inducible T cell costimulator [Source:HGNC Symbol;Acc:HGNC:5351] |
| Ensembl ID | ENSG00000163600 |
| Bio databases IDs | |
| Aliases | inducible T cell costimulator, activation-inducible lymphocyte immunomediatory molecule |
| Synonyms | AILIM,CCLP,CD278,CRP-1,CVID1,H4,inducible T-cell co-stimulator,LOC100048841,Ly115 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PI3K binding domain
- extracellular domain
- signaling receptor activity
- costimulatory domain
- YMFM Src homology 2 domain-binding motif
- immunoglobulin domain
- protein binding
- Src-homology 2 binding domain
- ICOS V-set domain
- phosphorylation site
- cytoplasmic domain
- immunoglobulin-like protein domain
- intracellular domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the ICOS gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TNF
- ICOSLG
- AHR
- FBXL18
- ZBTB16
- PTPN6
- ITK
- PI3K p85
- STAT3
- PCDH1
disease
- neoplasia
- cancer
- infection
- hyperplasia
- rheumatoid arthritis
- systemic lupus erythematosus
- insulitis
- experimental autoimmune myositis
- splenomegaly
- tumorigenesis
regulated by
- INSR
- IL6
- TNF
- T lymphocytes
- IL4
- NFkB (complex)
- CD3 (complex)
- CD28
- sirolimus
- MYD88
regulates
- IL1B
- Ca2+
- NFkB (complex)
- CXCL8
- IL4
- STAT5A/B
- p85 PIK3R
- ERK
- IFNG
- IL17A
role in cell
- maturation
- formation
- formation in
- expression in
- accumulation
- survival
- growth
- differentiation
- apoptosis
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- Nucleus
- immunological synapses
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ICOS gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- immune response
- T cell costimulation
- T cell tolerance induction
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular region
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding