PPARGC1B Gene Summary [Human]
The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | PPARGC1B |
| Official Name | PPARG coactivator 1 beta [Source:HGNC Symbol;Acc:HGNC:30022] |
| Ensembl ID | ENSG00000155846 |
| Bio databases IDs | |
| Aliases | PPARG coactivator 1 beta, PPARgamma coactivator 1 beta |
| Synonyms | 4631412G21Rik, ERRL1, LOC153346, PERC, peroxisome proliferative activated receptor, gamma, coactivator 1 beta, peroxisome proliferative activated receptor, γ, coactivator 1 β, PGC1B, PGC-1beta, PGC-1(beta), PGC-1beta/ERRL1, PGC-1(β), Pgc1 β, PPARGC-1-beta, PPARGC-1-β, PPARG coactivator 1 beta, PPARG coactivator 1 β |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPARGC1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- transcription regulator
- leucine rich domain
- LXXLL motif
- transcription co-activator
- AF-2 domain binding
- RNA recognition motif
- transcription cofactor
- protein binding
- estrogen receptor binding
Pathways
Biological processes and signaling networks where the PPARGC1B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- epithelial cancer
- squamous cell cancer
- epithelial basal cell carcinoma
- obesity
- Huntington disease
- sunburn
- androgenic alopecia
- macrovesicular hepatic steatosis
- cutaneous melanoma
role in cell
- function
- expression in
- quantity
- proliferation
- apoptosis
- synthesis in
- size
- activity
- differentiation
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nuclear foci
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPARGC1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of phosphorylation
- transcription from mitochondrial promoter
- actin filament organization
- regulation of transcription, DNA-dependent
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- bone trabecula formation
- negative regulation of transcription, DNA-dependent
- positive regulation of osteoclast differentiation
- ossification
- positive regulation of bone resorption
- cellular response to reactive oxygen species
- intracellular estrogen receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- mediator complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity
- RNA binding
- AF-2 domain binding
- ligand-dependent nuclear receptor transcription coactivator activity
- estrogen receptor binding
- transcription factor binding