GTSE1 Gene Summary [Human]
The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GTSE1 |
| Official Name | G2 and S-phase expressed 1 [Source:HGNC Symbol;Acc:HGNC:13698] |
| Ensembl ID | ENSG00000075218 |
| Bio databases IDs | |
| Aliases | G2 and S-phase expressed 1 |
| Synonyms | B99, G2 and S PHASE EXPRESSED 1, G two S phase expressed protein 1, RGD1563164 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GTSE1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-2 and S-phase expressed 1
- protein binding
- Rev activation domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- invasive breast cancer
- neoplasia
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- uterine carcinosarcoma
- Müllerian cancer
- uterine cancer
- chromosomal instability
role in cell
- binding in
- migration
- apoptosis
- orientation
- cell cycle progression
- missegregation
- stabilization in
- degradation in
- missegregation in
- migratory capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubules
- cytosol
- nucleoplasm
- cytoplasmic microtubule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GTSE1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- microtubule-based process
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- membrane
- cytosol
- cytoplasmic microtubule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule binding