KLF13 Gene Summary [Human]
KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | KLF13 |
| Official Name | Kruppel like factor 13 [Source:HGNC Symbol;Acc:HGNC:13672] |
| Ensembl ID | ENSG00000169926 |
| Bio databases IDs | |
| Aliases | Kruppel like factor 13, KLF transcription factor 13 |
| Synonyms | 0610043C13Rik, 9430029L20RIK, BTEB3, FKLF-2, KLF transcription factor 13, Kruppel-like transcription factor 13, LOC100499221, NSLP1, RFLAT-1, RGD1565099 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLF13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins
- transcription regulator
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- alanine-proline rich region
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription repression domain
- serine-rich region
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pelvic organ prolapse
- thyroid carcinoma
- epithelial thyroid cancer
- Down syndrome
- rheumatoid arthritis
- psoriasis
- non-insulin-dependent diabetes mellitus
- hyperplasia
- glomerulonephritis
role in cell
- expression in
- proliferation
- apoptosis
- colony formation by
- migration
- cell viability
- differentiation
- number
- quantity
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLF13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of erythrocyte differentiation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity