KLF9 Gene Summary [Human]
The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | KLF9 |
| Official Name | Kruppel like factor 9 [Source:HGNC Symbol;Acc:HGNC:1123] |
| Ensembl ID | ENSG00000119138 |
| Bio databases IDs | |
| Aliases | Kruppel like factor 9, KLF transcription factor 9 |
| Synonyms | 2310051E17RIK, BTEB, BTEB-1, Gm9971, KLF transcription factor 9, Kruppel-like transcription factor 9 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLF9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins
- transcription regulator
- transcription repression domain
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- sequence-specific DNA binding
- transcription factor activity
- DNA binding
Pathways
Biological processes and signaling networks where the KLF9 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hyperplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- metastasis
- Hutchinson-Gilford progeria syndrome
- preeclampsia
- acute myeloid leukemia
- endometrial cancer
role in cell
- expression in
- activation in
- proliferation
- apoptosis
- formation
- production in
- upregulation in
- recruitment in
- differentiation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Plasma Membrane
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLF9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of keratinocyte proliferation
- cellular response to cortisol stimulus
- circadian rhythm
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity