RGMA Gene Summary [Human]
This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | RGMA |
| Official Name | repulsive guidance molecule BMP co-receptor a [Source:HGNC Symbol;Acc:HGNC:30308] |
| Ensembl ID | ENSG00000182175 |
| Bio databases IDs | |
| Aliases | repulsive guidance molecule BMP co-receptor a |
| Synonyms | C230063O06, LOC56963, repulsive guidance molecule BMP co-receptor a, repulsive guidance molecule family member A, RGM |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RGMA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Repulsive guidance molecule (RGM) N-terminus
- Repulsive guidance molecule (RGM) C-terminus
- protein binding
- receptor binding
- coreceptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- exencephaly
- survival
- critical COVID-19
- ductal breast carcinoma
- ductal breast cancer
- motor dysfunction
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
role in cell
- migration
- expression in
- phosphorylation in
- proliferation
- apoptosis
- activation
- number
- collapse
- colony formation by
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- fimbria
- cell surface
- Endoplasmic Reticulum
- axons
- callosal axon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RGMA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of collateral sprouting
- negative regulation of axon regeneration
- neural tube closure
- membrane protein ectodomain proteolysis
- positive regulation of membrane protein ectodomain proteolysis
- neuron projection development
- BMP signaling pathway
- positive regulation of neuron projection development
- regulation of BMP signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- protein binding