Rgma Gene Summary [Mouse]
Enables coreceptor activity and signaling receptor binding activity. Acts upstream of or within several processes, including BMP signaling pathway; nervous system development; and positive regulation of membrane protein ectodomain proteolysis. Located in cell surface. Is expressed in several structures, including future brain; gut; nervous system; sensory organ; and trunk somite. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human RGMA (repulsive guidance molecule BMP co-receptor a). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgma |
| Official Name | repulsive guidance molecule family member A [Source:MGI Symbol;Acc:MGI:2679262] |
| Ensembl ID | ENSMUSG00000070509 |
| Bio databases IDs | |
| Aliases | repulsive guidance molecule family member A |
| Synonyms | C230063O06, LOC56963, repulsive guidance molecule BMP co-receptor a, repulsive guidance molecule family member A, RGM |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rgma often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Repulsive guidance molecule (RGM) N-terminus
- Repulsive guidance molecule (RGM) C-terminus
- protein binding
- receptor binding
- coreceptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- exencephaly
- survival
- critical COVID-19
- ductal breast carcinoma
- ductal breast cancer
- motor dysfunction
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
role in cell
- migration
- expression in
- phosphorylation in
- proliferation
- apoptosis
- activation
- number
- collapse
- colony formation by
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- fimbria
- cell surface
- Endoplasmic Reticulum
- axons
- callosal axon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rgma gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of collateral sprouting
- negative regulation of axon regeneration
- neural tube closure
- membrane protein ectodomain proteolysis
- positive regulation of membrane protein ectodomain proteolysis
- neuron projection development
- BMP signaling pathway
- positive regulation of neuron projection development
- regulation of BMP signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- protein binding