NEO1 Gene Summary [Human]
This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Details
| Type | Protein Coding |
| Official Symbol | NEO1 |
| Official Name | neogenin 1 [Source:HGNC Symbol;Acc:HGNC:7754] |
| Ensembl ID | ENSG00000067141 |
| Bio databases IDs | |
| Aliases | neogenin 1, immunoglobulin superfamily, DCC subclass, member 2 |
| Synonyms | 2610028H22RIK, D930014N22RIK, IGDCC2, Neogenin, neogenin 1, NGN, NTN1R2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NEO1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Neogenin C-terminus
- signaling receptor activity
- Immunoglobulin V-Type
- immunoglobulin domain
- ectodomain
- Purple acid Phosphatase, N-terminal domain
- Immunoglobulin I-set domain
- protein binding
- receptor binding
- Fibronectin type 3 domain
- cytoplasmic domain
- FN3
- transmembrane domain
- Immunoglobulin like
- intracellular domain
- cadherin binding
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the NEO1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- depressive disorder
- metabolic syndrome X
- atrial fibrillation
- metastasis
- dental caries
- gout
- early missed abortion
- iron overload
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
role in cell
- growth
- expression in
- cell death
- phosphorylation in
- quantity
- proliferation
- activation in
- number
- formation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- fimbria
- glutaminergic synapse
- intracellular membrane-bounded organelle
- cell surface
- cellular membrane
- vesicles
- Golgi Apparatus
- synaptic membrane
- nucleoplasm
- synaptic vesicles
- growth cone
- membrane rafts
- cell membrane leading edge
- perikaryon
- axons
- callosal axon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NEO1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- positive regulation of BMP signaling pathway
- negative regulation of axon regeneration
- neuron migration
- multicellular organismal iron ion homeostasis
- negative regulation of protein secretion
- myoblast fusion
- axon guidance
- regulation of transcription, DNA-dependent
- cell adhesion
- protein secretion
Cellular Component
Where in the cell the gene product is active
- axonal growth cone
- Golgi apparatus
- plasma membrane
- nucleoplasm
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- signaling receptor activity
- BMP receptor binding