Rgma Gene Summary [Rat]
Predicted to enable coreceptor activity and transferrin receptor binding activity. Involved in negative regulation of axon regeneration; negative regulation of collateral sprouting; and positive regulation of neuron projection development. Predicted to be located in cell surface and endoplasmic reticulum. Predicted to be active in plasma membrane. Used to study middle cerebral artery infarction. Biomarker of middle cerebral artery infarction; sciatic neuropathy; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human RGMA (repulsive guidance molecule BMP co-receptor a). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgma |
| Official Name | repulsive guidance molecule BMP co-receptor a [Source:RGD Symbol;Acc:1311983] |
| Ensembl ID | ENSRNOG00000012874 |
| Bio databases IDs | |
| Aliases | repulsive guidance molecule BMP co-receptor a |
| Synonyms | C230063O06, LOC56963, repulsive guidance molecule BMP co-receptor a, repulsive guidance molecule family member A, RGM |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rgma often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Repulsive guidance molecule (RGM) N-terminus
- Repulsive guidance molecule (RGM) C-terminus
- protein binding
- receptor binding
- coreceptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- exencephaly
- survival
- critical COVID-19
- ductal breast carcinoma
- ductal breast cancer
- motor dysfunction
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
role in cell
- migration
- expression in
- phosphorylation in
- proliferation
- apoptosis
- activation
- number
- collapse
- colony formation by
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- fimbria
- cell surface
- Endoplasmic Reticulum
- axons
- callosal axon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rgma gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of collateral sprouting
- negative regulation of axon regeneration
- neural tube closure
- membrane protein ectodomain proteolysis
- positive regulation of membrane protein ectodomain proteolysis
- neuron projection development
- BMP signaling pathway
- positive regulation of neuron projection development
- regulation of BMP signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- protein binding