Il18rap Gene Summary [Rat]
Predicted to enable coreceptor activity and interleukin-18 receptor activity. Involved in cellular response to cytokine stimulus and cellular response to hydrogen peroxide. Predicted to be part of interleukin-18 receptor complex. Predicted to be active in cell surface and plasma membrane. Orthologous to human IL18RAP (interleukin 18 receptor accessory protein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il18rap |
| Official Name | interleukin 18 receptor accessory protein [Source:RGD Symbol;Acc:727867] |
| Ensembl ID | ENSRNOG00000054218 |
| Bio databases IDs | |
| Aliases | interleukin 18 receptor accessory protein |
| Synonyms | ACPL, CD218b, CDw218b, Il18acpl, IL-18RAcP, IL18RB, IL-18R-beta, IL-18R-β, IL-1R-7, IL-1RAcPL, interleukin 18 receptor accessory protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il18rap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- interleukin-18 binding
- interleukin-18 receptor
- immunoglobulin domain
- Immunoglobulin like
- SEFIR domain
- protein binding
- TIR domain
- transmembrane receptor
- coreceptor
Pathways
Biological processes and signaling networks where the Il18rap gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Glucocorticoid Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Natural Killer Cell Signaling
- Osteoarthritis Pathway
- p38 MAPK Signaling
- PPAR Signaling
- PPARα/RXRα Activation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- STAT3 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rhinitis
- Crohn disease
- endometriosis
- atopic dermatitis
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- inflammatory bowel disease
- systemic lupus erythematosus
- septic shock
- limited systemic sclerosis
role in cell
- proliferation
- binding
- activation
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il18rap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- neutrophil activation
- inflammatory response
- immune response
- cellular response to hydrogen peroxide
- positive regulation of NF-kappaB transcription factor activity
- interleukin-18-mediated signaling pathway
- positive regulation of natural killer cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- interleukin-18 receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- interleukin-18 receptor activity
- coreceptor activity
- NAD+ nucleosidase activity
- protein binding