PON1 Gene Summary

This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7. [provided by RefSeq, Aug 2017]

Details

Type
Protein Coding
Official Symbol
PON1
Official Name
paraoxonase 1 [Source:HGNC Symbol;Acc:HGNC:9204]
Ensembl ID
ENSG00000005421
Bio databases IDs NCBI: 5444 Ensembl: ENSG00000005421
Aliases paraoxonase 1, esterase A, arylesterase 1
Synonyms
A-esterase 1,ESA,MVCD5,PARAOXONASE 1,PON
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • phospholipid binding
  • aryldialkylphosphatase
  • strictosidine synthase
  • phosphatase
  • calcium ion binding
  • high-density lipoprotein binding
  • protein homodimerization
  • arylesterase
  • enzyme
  • lactonohydrolase

Pathways

Biological processes and signaling networks where the PON1 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • COVID-19
  • myocardial infarction
  • thrombosis
  • coronary disease
  • Alzheimer disease
  • colitis
  • epithelial cancer
  • hepatocellular carcinoma
  • liver cancer
  • atherosclerosis
regulated by
  • quercetin
  • Ca2+
  • PPARA
  • beta-estradiol
  • berberine
  • APOE
  • metformin
  • pravastatin
  • 4-hydroxynonenal
  • (S)-mevalonic acid
regulates
role in cell
  • cell death
  • quantity
  • phagocytosis by
  • proinflammatory response
  • response
  • signaling in
  • bioactivation in
  • volume

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • membrane fraction
  • Cytoplasm
  • Nucleus
  • endoplasmic reticulum membrane
  • outer leaflet
  • Golgi membrane
  • plasma
  • detergent-soluble fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the PON1 gene, providing context for its role in the cell.

biological PROCESS

Functions and activities the gene product is involved in
  • carboxylic acid catabolic process
  • phosphatidylcholine metabolic process
  • cholesterol metabolic process
  • positive regulation of cholesterol efflux
  • negative regulation of plasma lipoprotein particle oxidation
  • organophosphate catabolic process
  • response to toxin

cellular COMPONENT

Where in the cell the gene product is active
  • endoplasmic reticulum membrane
  • extracellular space
  • extracellular vesicular exosome
  • high-density lipoprotein particle
  • blood microparticle
  • spherical high-density lipoprotein particle
  • extracellular region

molecular FUNCTION

What the gene product does at the molecular level
  • protein homodimerization activity
  • calcium ion binding
  • aryldialkylphosphatase activity
  • arylesterase activity
  • phospholipid binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.