STMN1 Gene Summary
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Details
| Type | Processed Transcript |
| Official Symbol | STMN1 |
| Official Name | stathmin 1 [Source:HGNC Symbol;Acc:HGNC:6510] |
| Ensembl ID | ENSG00000117632 |
| Bio databases IDs | |
| Aliases | stathmin 1, oncoprotein 18 |
| Synonyms | 19k,C1orf215,FLJ32206,Lag,LAP18,Metablastin,OP18,P18,P19,Phosphoprotein p19,Pig,PP17,Pp18,PP19,PR22,Prosolin,SMN,Stathmin,Stathmin1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tubulin binding domain
- tubulin binding
- serine phosphorylation site
- protein binding
- Stathmin family
- phosphorylation site
Pathways
Biological processes and signaling networks where the STMN1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-small cell lung cancer
- adenoid cystic carcinoma
- epithelial cancer
- axonopathy
- glioblastoma
- glioblastoma cancer
- mammary neoplasm
- renal failure
- gliosis
role in cell
- apoptosis
- activation in
- cell death
- growth
- quantity
- proliferation
- expression in
- cell viability
- differentiation
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
- synaptic vesicles
- growth cone
- cellular protrusions
- mitotic spindle
- perikaryon
- dendrites
- axon terminals
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the STMN1 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- negative regulation of Rho protein signal transduction
- signal transduction
- neuron projection development
- mitotic spindle organization
- response to virus
- microtubule depolymerization
- establishment of skin barrier
- hepatocyte growth factor receptor signaling pathway
- negative regulation of stress fiber assembly
- axonogenesis
- cytokinesis after mitosis
- negative regulation of thrombin receptor signaling pathway
- regulation of microtubule polymerization or depolymerization
- regulation of cell migration
- intracellular signal transduction
- negative regulation of microtubule polymerization
cellular COMPONENT
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- neuron projection
- microtubule
molecular FUNCTION
What the gene product does at the molecular level
- tubulin binding
- protein binding