ID2
ID2 Gene Summary
The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | ID2 |
| Official Name | inhibitor of DNA binding 2 [Source:HGNC Symbol;Acc:HGNC:5361] |
| Ensembl ID | ENSG00000115738 |
| Bio databases IDs | |
| Aliases | inhibitor of DNA binding 2, cell growth-inhibiting gene 8 |
| Synonyms | Ac2-300,bHLHb26,C78922,GIG8,ID2A,ID2H,IDB2,inhibitor of binding 2, dominant negative helix-loop-helix,Inhibitor Of DNA Binding 2,inhibitor of DNA binding 2, dominant negative helix-loop-helix |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cdk2 phosphorylation site
- transcription regulator
- nuclear localization sequence
- basic Helix Loop Helix (bHLH) domain superfamily
- ion channel binding
- helix loop helix domain
- transcription factor binding
- helix-loop-helix domain
- protein binding
Pathways
Biological processes and signaling networks where the ID2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CDK1
- CDC27
- MAX
- CHD4
- RIN3
- MSGN1
- HTRA2
- TCF4
- TCF3
- SMURF2
disease
- small cell lung cancer
- neoplasia
- epithelial cancer
- cancer
- metastasis
- prostatic adenocarcinoma
- prostate cancer
- lymphomagenesis
- epileptic seizure
- ureteropelvic junction stenosis
regulated by
- tetradecanoylphorbol acetate
- TGFB1
- TP53
- MPZ
- SSRP1
- Salmonella enterica serotype abortus equi lipopolysaccharide
- MYC
- IGF1
- MEK
- TCF7
regulates
- BCL2L1
- FOS
- FAS
- BCL2
- HIF1A
- FOXO1
- MMP9
- ELK1
- DTX2
- FOXO3
role in cell
- quantity
- proliferation
- production in
- binding in
- expression in
- number
- damage in
- cell death
- growth
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ID2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- epithelial cell differentiation involved in mammary gland alveolus development
- endodermal digestive tract morphogenesis
- cellular senescence
- positive regulation of fat cell differentiation
- positive regulation of astrocyte differentiation
- embryonic digestive tract morphogenesis
- regulation of neuron differentiation
- regulation of circadian rhythm
- olfactory bulb development
- positive regulation of smooth muscle cell proliferation
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of muscle cell differentiation
- heart development
- circadian regulation of gene expression
- mammary gland alveolus development
- negative regulation of transcription, DNA-dependent
- locomotor rhythm
- positive regulation of transcription, DNA-dependent
- positive regulation of macrophage differentiation
- neuron fate commitment
- entrainment of circadian clock by photoperiod
- mammary gland epithelial cell proliferation
- regulation of neural precursor cell proliferation
- enucleate erythrocyte differentiation
- negative regulation of B cell differentiation
- negative regulation of sequence-specific DNA binding transcription factor activity
- bundle of His development
- circadian rhythm
- positive regulation of blood pressure
- regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- positive regulation of gene expression
- cell differentiation
- regulation of G1/S transition of mitotic cell cycle
- regulation of lipid metabolic process
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- euchromatin
- cytoplasm
- cytosol
- macromolecular complex
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- protein dimerization activity
- ion channel binding