LATS2 Gene Summary [Human]
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LATS2 |
| Official Name | large tumor suppressor kinase 2 [Source:HGNC Symbol;Acc:HGNC:6515] |
| Ensembl ID | ENSG00000150457 |
| Bio databases IDs | |
| Aliases | large tumor suppressor kinase 2 |
| Synonyms | 4932411G09Rik, KPM, large tumor suppressor 2, large tumor suppressor kinase 2, large tumour suppressor 2, large tumour suppressor kinase 2, Lats2 predicted |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LATS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- MOB1-binding region
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein kinase C terminal domain
- ATP binding
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- Tyrosine kinase, catalytic domain
- Mob-binding domain found in the NDR/LATS family serine/threonine protein kinases
- hydrophobic domain
Pathways
Biological processes and signaling networks where the LATS2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- cancer
- neoplasia
- cryptorchidism
- melanoma cancer
- androgenic alopecia
- developmental delay
- liver cancer
- digestive system cancer
role in cell
- differentiation
- proliferation
- binding in
- quantity
- survival
- apoptosis
- growth
- migration
- cell viability
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- vesicles
- centrosome
- cytosol
- spindle pole
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LATS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein localization to nucleus
- protein localization
- regulation of organ growth
- protein phosphorylation
- negative regulation of cyclin-dependent protein kinase activity
- hormone-mediated signaling pathway
- negative regulation of canonical Wnt receptor signaling pathway
- cell division
- keratinocyte differentiation
- positive regulation of apoptotic process
- G1/S transition of mitotic cell cycle
- canonical Wnt receptor signaling pathway
- inner cell mass cell fate commitment
- hippo signaling cascade
- inner cell mass cellular morphogenesis
- regulation of transforming growth factor beta receptor signaling pathway
- peptidyl-serine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- centriolar satellite
- spindle pole
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein serine/threonine kinase activity