Irak3 Gene Summary [Mouse]
Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of macromolecule metabolic process; regulation of innate immune response; and response to molecule of bacterial origin. Acts upstream of or within interleukin-1-mediated signaling pathway; positive regulation of NF-kappaB transcription factor activity; and protein autophosphorylation. Located in cytoplasm and nucleus. Used to study osteoporosis and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IRAK3 (interleukin 1 receptor associated kinase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Irak3 |
| Official Name | interleukin-1 receptor-associated kinase 3 [Source:MGI Symbol;Acc:MGI:1921164] |
| Ensembl ID | ENSMUSG00000020227 |
| Bio databases IDs | |
| Aliases | interleukin-1 receptor-associated kinase 3 |
| Synonyms | 4833428C18Rik, ASRT5, DKFZp586B0220, interleukin-1 receptor-associated kinase 3, IRAK-M |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Irak3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- enzyme
- magnesium ion binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- protein homodimerization
- Tyrosine kinase, catalytic domain
- Death Domain Superfamily of protein-protein interaction domains
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Irak3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sepsis
- osteoporosis
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- susceptibility to asthma-related traits type 5
- edema
- insulin-dependent diabetes mellitus
- early-onset persistent asthma
- androgenic alopecia
- weight gain
- neonatal late-onset sepsis
role in cell
- phosphorylation in
- apoptosis
- production in
- activation in
- expression in
- generation in
- number
- survival
- differentiation
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Irak3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Toll signaling pathway
- negative regulation of MAP kinase activity
- response to peptidoglycan
- regulation of protein complex disassembly
- negative regulation of protein catabolic process
- protein phosphorylation
- response to virus
- positive regulation of NF-kappaB transcription factor activity
- negative regulation of innate immune response
- negative regulation of cytokine-mediated signaling pathway
- MyD88-dependent toll-like receptor signaling pathway
- positive regulation of macrophage tolerance induction
- response to exogenous dsRNA
- cytokine-mediated signaling pathway
- negative regulation of macrophage cytokine production
- negative regulation of tumor necrosis factor production
- intracellular signal transduction
- negative regulation of toll-like receptor signaling pathway
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of interleukin-6 production
- cellular response to lipopolysaccharide
- negative regulation of protein complex disassembly
- response to interleukin-1
- response to lipopolysaccharide
- interleukin-1-mediated signaling pathway
- negative regulation of interleukin-12 production
- positive regulation of cytokine production
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein kinase binding
- protein homodimerization activity
- protein binding
- protein heterodimerization activity
- protein serine/threonine kinase activity