IRAK3
IRAK3 Gene Summary
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | IRAK3 |
| Official Name | interleukin 1 receptor associated kinase 3 [Source:HGNC Symbol;Acc:HGNC:17020] |
| Ensembl ID | ENSG00000090376 |
| Bio databases IDs | |
| Aliases | interleukin 1 receptor associated kinase 3 |
| Synonyms | 4833428C18Rik,ASRT5,DKFZp586B0220,interleukin-1 receptor-associated kinase 3,IRAK-M |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- enzyme
- magnesium ion binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- protein homodimerization
- Tyrosine kinase, catalytic domain
- Death Domain Superfamily of protein-protein interaction domains
- protein heterodimerization
Pathways
Biological processes and signaling networks where the IRAK3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- MYD88
- IRAK1
- CASP6
- HSP90AB1
- IRAK2
- TRAF6
- NR3C1
- HSPB8
- IRAK3
- HSP90AA1
disease
- sepsis
- osteoporosis
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- susceptibility to asthma-related traits type 5
- edema
- insulin-dependent diabetes mellitus
- early-onset persistent asthma
- androgenic alopecia
- weight gain
- neonatal late-onset sepsis
regulated by
- lipopolysaccharide
- dexamethasone
- CSF
- IL4
- TNF (family)
- IL1B
- TNF
- RAW 264.7 cells
- bone marrow-derived macrophages
- E. coli B4 lipopolysaccharide
regulates
- TNF
- CXCL8
- CCL2
- ACTA2
- JNK
- Cxcl1
- NFKBIA
- Cxcl2
- COL1A1
- IL6
role in cell
- phosphorylation in
- apoptosis
- production in
- activation in
- expression in
- generation in
- number
- survival
- differentiation
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the IRAK3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- Toll signaling pathway
- negative regulation of MAP kinase activity
- response to peptidoglycan
- regulation of protein complex disassembly
- negative regulation of protein catabolic process
- protein phosphorylation
- response to virus
- positive regulation of NF-kappaB transcription factor activity
- negative regulation of innate immune response
- negative regulation of cytokine-mediated signaling pathway
- MyD88-dependent toll-like receptor signaling pathway
- positive regulation of macrophage tolerance induction
- response to exogenous dsRNA
- cytokine-mediated signaling pathway
- negative regulation of macrophage cytokine production
- negative regulation of tumor necrosis factor production
- intracellular signal transduction
- negative regulation of toll-like receptor signaling pathway
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of interleukin-6 production
- cellular response to lipopolysaccharide
- negative regulation of protein complex disassembly
- response to interleukin-1
- response to lipopolysaccharide
- interleukin-1-mediated signaling pathway
- negative regulation of interleukin-12 production
- positive regulation of cytokine production
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein kinase binding
- protein homodimerization activity
- protein binding
- protein heterodimerization activity
- protein serine/threonine kinase activity