Mgat1 Gene Summary [Mouse]
Enables acetylglucosaminyltransferase activity. Acts upstream of or within UDP-N-acetylglucosamine catabolic process and in utero embryonic development. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including decidua; early conceptus; embryo ectoderm; embryo endoderm; and retina outer nuclear layer. Orthologous to human MGAT1 (alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mgat1 |
| Official Name | mannoside acetylglucosaminyltransferase 1 [Source:MGI Symbol;Acc:MGI:96973] |
| Ensembl ID | ENSMUSG00000020346 |
| Bio databases IDs | |
| Aliases | mannoside acetylglucosaminyltransferase 1 |
| Synonyms | alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, GLCNAC-TI, GLCT1, GLYT1, GNT-1, GNT-I, LOC102724833, mannoside acetylglucosaminyltransferase 1, MGAT, N-Acetylglucosamine transferase-I, N-acetylglucosaminyltransferase i, SCH4, α-1,3-mannosyl-glycoprotein 2-β-N-acetylglucosaminyltransferase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mgat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- GNT-I family
- acetylglucosaminyltransferase
- enzyme
- protein binding
- manganese ion binding
- glycosyltransferase family A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- bleeding
- growth failure
- left ventricular dilation
- anemia
- situs inversus totalis
- aldosterone producing adrenocortical adenoma
- adenoma formation
- androgenic alopecia
- systolic dysfunction
role in cell
- growth
- cell viability
- expression in
- replication in
- abnormal morphology
- phosphorylation in
- proliferation
- contraction
- cell-cell adhesion
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- centrosome
- Golgi Apparatus
- Golgi membrane
- spindle pole
- cleavage furrow
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mgat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral protein processing
- in utero embryonic development
- protein N-linked glycosylation
- protein N-linked glycosylation via asparagine
- UDP-N-acetylglucosamine catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- membrane
- Golgi apparatus
- Golgi membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- acetylglucosaminyltransferase activity
- alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
- manganese ion binding