Fasl Gene Summary [Mouse]
Predicted to enable cytokine activity; death receptor binding activity; and tumor necrosis factor receptor binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors and retinal cell programmed cell death. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system gland; reproductive system; and trophectoderm. Used to study autoimmune lymphoproliferative syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fasl |
| Official Name | Fas ligand (TNF superfamily, member 6) [Source:MGI Symbol;Acc:MGI:99255] |
| Ensembl ID | ENSMUSG00000000817 |
| Bio databases IDs | |
| Aliases | Fas ligand (TNF superfamily, member 6) |
| Synonyms | ALPS1B, APT1LG1, APTL, CD178, CD95-L, FASL, Fas Ligand, gld, mFasL, Tnfl6, TNFSF6, TNLG1A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fasl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- death receptor binding
- TNF homology domain
- tumor necrosis factor receptor binding
- TNF
- protein binding
- receptor binding
- cytokine
- proline rich domain
- cytoplasmic domain
- transmembrane domain
- intracellular domain
- Casein kinase I binding site
Pathways
Biological processes and signaling networks where the Fasl gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- vascular leak syndrome
- rheumatoid arthritis
- autoimmune disease
- kidney disease
- X-linked immunodeficiency 98 with autoinflammation
- toxic epidermal necrolysis
- splenomegaly
- metastasis
phenotypes
- CNS inflammation
- abnormal NK cell physiology
- abnormal T cell differentiation
- abnormal T cell morphology
- abnormal T cell physiology
- abnormal T cell proliferation
- abnormal cytotoxic T cell physiology
- abnormal definitive hematopoiesis
- abnormal double-negative T cell morphology
- abnormal eye electrophysiology
- abnormal hepatocyte morphology
- abnormal humoral immune response
- abnormal interleukin level
- abnormal lymph node morphology
- abnormal osteoclast physiology
- abnormal retinal ganglion cell morphology
- abnormal retinal nerve fiber layer morphology
- abnormal salivary gland morphology
- abnormal sperm number
- abnormal sperm physiology
- abnormal thymus cell ratio
- anemia
- autoimmune response
- brain inflammation
- decreased B cell number
- decreased IgG level
- decreased circulating alanine transaminase level
- decreased cytotoxic T cell cytolysis
- decreased granulocyte number
- decreased hepatocyte apoptosis
- decreased neuron apoptosis
- decreased retinal ganglion cell number
- decreased susceptibility to injury
- demyelination
- dermatitis
- enlarged liver
- enlarged lymph nodes
- enlarged spleen
- enlarged thymus
- eye inflammation
- focal hepatic necrosis
- glomerular crescent
- glomerulonephritis
- impaired humoral immune response
- impaired macrophage phagocytosis
- increased B cell proliferation
- increased IgA level
- increased IgE level
- increased IgG level
- increased IgG1 level
- increased IgG2a level
- increased IgG2b level
- increased IgM level
- increased T cell number
- increased T cell proliferation
- increased anti-double stranded DNA antibody level
- increased anti-nuclear antigen antibody level
- increased apoptosis
- increased autoantibody level
- increased circulating tumor necrosis factor level
- increased germinal center B cell number
- increased histiocytic sarcoma incidence
- increased immunoglobulin level
- increased leukocyte cell number
- increased liver tumor incidence
- increased lymphocyte cell number
- increased lymphoma incidence
- increased metastatic potential
- increased neutrophil cell number
- increased plasma cell number
- increased retinal apoptosis
- increased spleen weight
- increased susceptibility to Picornaviridae infection
- increased susceptibility to bacterial infection
- increased susceptibility to systemic lupus erythematosus
- increased urine protein level
- interstitial pneumonia
- liver inflammation
- lymphoid hyperplasia
- no abnormal phenotype detected
- premature death
- renal cast
- retinal ganglion cell degeneration
- skin edema
role in cell
- expression in
- cell viability
- apoptosis
- osteoclastogenesis
- accumulation
- activation in
- production
- phosphorylation in
- activation
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- lysosome fractions
- Cytoplasm
- cell surface
- intracellular space
- perinuclear region
- microvesicles
- membrane surface
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- lysosome
- Golgi Apparatus
- intermediate filaments
- plasma membrane extracellular face
- caveolae
- lysosome membrane
- neurites
- cytoplasmic vesicles
- melanosomes
- multivesicular bodies
- membrane rafts
- membrane processes
- perikaryon
- exosomes
- plasma
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fasl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- response to growth factor stimulus
- positive regulation of cell proliferation
- extrinsic apoptotic signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of epidermal growth factor receptor signaling pathway
- apoptotic signaling pathway
- induction of apoptosis via death domain receptors
- positive regulation of neuron apoptotic process
- negative regulation of transcription from RNA polymerase II promoter
- necroptosis
- endosomal lumen acidification
- apoptotic process
- positive regulation of endothelial cell apoptotic process
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- cellular chloride ion homeostasis
- signal transduction
- retinal cell programmed cell death
- cell-cell signaling
- inflammatory cell apoptotic process
- T cell apoptotic process
- positive regulation of apoptotic process
- response to lipopolysaccharide
- cellular response to interferon-gamma
Cellular Component
Where in the cell the gene product is active
- nucleus
- caveola
- extracellular space
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- external side of plasma membrane
- lysosomal lumen
- extracellular region
- plasma membrane
- cytoplasmic membrane-bounded vesicle lumen
Molecular Function
What the gene product does at the molecular level
- protein binding
- tumor necrosis factor receptor binding
- death receptor binding
- cytokine activity
- receptor binding