Sorbs3 Gene Summary [Mouse]
Predicted to enable vinculin binding activity. Acts upstream of or within cell-substrate adhesion; negative regulation of transcription by RNA polymerase II; and positive regulation of MAPK cascade. Located in cytoplasm; focal adhesion; and nucleus. Is expressed in several structures, including eye; gonad; heart; hindbrain; and long bone epiphysis. Orthologous to human SORBS3 (sorbin and SH3 domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sorbs3 |
| Official Name | sorbin and SH3 domain containing 3 [Source:MGI Symbol;Acc:MGI:700013] |
| Ensembl ID | ENSMUSG00000022091 |
| Bio databases IDs | |
| Aliases | sorbin and SH3 domain containing 3 |
| Synonyms | SCAM-1, SH3D4, SH3P3, sorbin and SH3 domain containing 3, VINE, vinexin-g, Vinexin α, Vinexin β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sorbs3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of cytoskeleton
- transcription factor binding
- protein binding
- vinculin binding
- fxfp sequence
- Sorbin homologous domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Sorbs3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- Turner syndrome
- Hutchinson-Gilford progeria syndrome
- Klinefelter syndrome
- human immunodeficiency virus I infection
role in cell
- proliferation
- formation
- migration
- size
- cell spreading
- assembly
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- focal adhesions
- Nucleus
- intercellular junctions
- cell-cell contacts
- cytoplasmic aggregates
- cytosol
- cell-matrix adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sorbs3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- MAPK cascade
- cytoskeleton organization
- positive regulation of cytoskeleton organization
- positive regulation of stress fiber assembly
- cell adhesion
- positive regulation of MAPK cascade
- cell-substrate adhesion
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- focal adhesion
- cytoplasm
- cell-substrate junction
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- vinculin binding
- structural constituent of cytoskeleton