P3h3 Gene Summary [Mouse]
Predicted to enable procollagen-proline 3-dioxygenase activity. Involved in collagen biosynthetic process and peptidyl-lysine hydroxylation. Part of catalytic complex. Is expressed in several structures, including branchial arch; embryo mesenchyme; genitourinary system; limb primordium; and sensory organ. Orthologous to human P3H3 (prolyl 3-hydroxylase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | P3h3 |
| Official Name | prolyl 3-hydroxylase 3 [Source:MGI Symbol;Acc:MGI:1315208] |
| Ensembl ID | ENSMUSG00000023191 |
| Bio databases IDs | |
| Aliases | prolyl 3-hydroxylase 3 |
| Synonyms | GRCB, HSU47926, LEPREL2, prolyl 3-hydroxylase 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse P3h3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- protein binding
- 2OG-Fe(II) oxygenase superfamily
- Prolyl 4-hydroxylase alpha subunit homologues
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse P3h3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-lysine hydroxylation
- negative regulation of cell proliferation
- collagen biosynthetic process
- collagen metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- L-ascorbic acid binding
- iron ion binding
- procollagen-proline 3-dioxygenase activity