G6pc3 Gene Summary [Mouse]
Enables glucose-6-phosphatase activity. Involved in gluconeogenesis. Acts upstream of or within glucose-6-phosphate transport. Is active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in severe congenital neutropenia 4. Orthologous to human G6PC3 (glucose-6-phosphatase catalytic subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | G6pc3 |
| Official Name | glucose 6 phosphatase, catalytic, 3 [Source:MGI Symbol;Acc:MGI:1915651] |
| Ensembl ID | ENSMUSG00000034793 |
| Bio databases IDs | |
| Aliases | glucose 6 phosphatase, catalytic, 3 |
| Synonyms | 0710001K01RIK, G6Pase-beta, G6Pase-β, GLUCOSE-6-PHOSPHATASE, glucose 6 phosphatase, catalytic, 3, glucose-6-phosphatase catalytic subunit 3, LOC303565, SCN4, UGRP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse G6pc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acid phosphatase homologues
- PAP2 superfamily
- phosphatase
- PAP2_like
- glucose-6-phosphatase
Pathways
Biological processes and signaling networks where the G6pc3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neutropenia
- autosomal recessive severe congenital neutropenia type 4
- severe congenital neutropenia
- multiple sclerosis
- growth failure
- chronic lymphocytic leukemia
- Dursun syndrome
- infection by bacteria
role in cell
- expression in
- accumulation in
- number
- phosphorylation in
- activation in
- apoptosis
- production in
- function
- trafficking
- gluconeogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse G6pc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
- glucose 6-phosphate metabolic process
- glucose-6-phosphate transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- glucose-6-phosphatase activity