Npy1r Gene Summary [Mouse]
Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Acts upstream of or within several processes, including feeding behavior; glucose metabolic process; and sensory perception of pain. Predicted to be located in axon and synaptic vesicle. Predicted to be active in several cellular components, including glutamatergic synapse; neuronal dense core vesicle; and presynaptic membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; immune system; and liver. Used to study obesity. Human ortholog(s) of this gene implicated in amphetamine abuse; cocaine abuse; heroin dependence; nicotine dependence; and opiate dependence. Orthologous to human NPY1R (neuropeptide Y receptor Y1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Npy1r |
| Official Name | neuropeptide Y receptor Y1 [Source:MGI Symbol;Acc:MGI:104963] |
| Ensembl ID | ENSMUSG00000036437 |
| Bio databases IDs | |
| Aliases | neuropeptide Y receptor Y1 |
| Synonyms | neuropeptide Y receptor Y1, NPY-1, NPYIR, NPYR, NPY receptor Y1, Y1-R, Y1 receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Npy1r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- peptide YY receptor
- pancreatic polypeptide receptor
- Cholecystokinin A receptor, N-terminal
- neuropeptide Y receptor
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Npy1r gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- cardiac fibrosis
- breast carcinoma
- gastric epithelial cancer
- hyperactive behavior
- obesity
- ischemic stroke
- delayed hypersensitive reaction
phenotypes
- abnormal T cell activation
- abnormal T cell number
- abnormal T-helper 1 physiology
- abnormal cardiovascular system physiology
- abnormal eating behavior
- abnormal energy expenditure
- abnormal glucose homeostasis
- abnormal glycogen level
- abnormal immune cell physiology
- abnormal immune system organ morphology
- abnormal immune system physiology
- abnormal immunoglobulin level
- abnormal inflammatory response
- abnormal lymph node cell ratio
- abnormal macrophage physiology
- abnormal neuron differentiation
- abnormal olfactory sensory neuron morphology
- abnormal postnatal subventricular zone morphology
- abnormal professional antigen presenting cell physiology
- abnormal rostral migratory stream morphology
- abnormal spleen morphology
- abnormal splenic cell ratio
- abnormal sympathetic system morphology
- abnormal vasoconstriction
- altered righting response
- cardiac interstitial fibrosis
- decreased B cell number
- decreased CD8-positive alpha-beta T cell number
- decreased IgG2a level
- decreased circulating interleukin-12 level
- decreased circulating tumor necrosis factor level
- decreased compensatory feeding amount
- decreased energy expenditure
- decreased exploration in new environment
- decreased food intake
- decreased heart rate
- decreased interferon-gamma secretion
- decreased marginal zone B cell number
- decreased mature B cell number
- decreased neuronal precursor cell number
- decreased oxygen consumption
- decreased sensitivity to xenobiotic induced morbidity/mortality
- decreased susceptibility to type IV hypersensitivity reaction
- decreased transitional stage B cell number
- hyperactivity
- hyperglycemia
- hypoactivity
- impaired behavioral response to alcohol
- impaired glucose tolerance
- increased CD4-positive alpha beta T cell number
- increased CD8-positive alpha-beta T cell number
- increased IgA level
- increased IgG2b level
- increased IgM level
- increased adipocyte glucose uptake
- increased aggression towards mice
- increased alcohol consumption
- increased body weight
- increased circulating corticosterone level
- increased circulating free fatty acid level
- increased circulating insulin level
- increased circulating leptin level
- increased epididymal fat pad weight
- increased gonadal fat pad weight
- increased immunoglobulin level
- increased litter size
- increased percent body fat/body weight
- increased retroperitoneal fat pad weight
- increased single-positive T cell number
- increased total body fat amount
- no abnormal phenotype detected
- obese
- small spleen
role in cell
- production in
- activation
- survival
- proliferation
- quantity
- function
- maturation
- number
- differentiation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cell surface
- cellular membrane
- presynaptic membrane
- synaptic vesicles
- secretory granules
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Npy1r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- neuropeptide signaling pathway
- regulation of multicellular organism growth
- locomotory behavior
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- outflow tract morphogenesis
- sensory perception of pain
- feeding behavior
- glucose metabolic process
- regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- neuropeptide binding
- protein binding
- peptide YY receptor activity
- neuropeptide receptor activity
- pancreatic polypeptide receptor activity
- neuropeptide Y receptor activity