Ptgs1 Gene Summary [Mouse]
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014]
Details
| Type | Protein Coding |
| Official Symbol | Ptgs1 |
| Official Name | prostaglandin-endoperoxide synthase 1 [Source:MGI Symbol;Acc:MGI:97797] |
| Ensembl ID | ENSMUSG00000047250 |
| Bio databases IDs | |
| Aliases | prostaglandin-endoperoxide synthase 1 |
| Synonyms | COX1, COX3, Cyclooxygenase 1, PCOX1, PES-1, PGG/HS, PGHS-1, PGH SYNTHASE, Pgs constitutive form, PHS 1, prostaglandin-endoperoxide synthase 1, PTGHS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptgs1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acetylation site
- peroxidase
- cyclooxygenase
- Animal haem peroxidase
- enzyme
- protein binding
- Animal heme peroxidases and related proteins
- paired donor oxygen oxidoreductase
- EGF_CA
Pathways
Biological processes and signaling networks where the Ptgs1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- heart disease
- cardiovascular disorder
- coronary disease
- hypercholesterolemia
- atherosclerosis
- dyslipidemia
- hyperlipidemia
- ST-elevation myocardial infarction
phenotypes
- abnormal blood coagulation
- abnormal blood flow velocity
- abnormal circadian regulation of heart rate
- abnormal circadian regulation of systemic arterial blood pressure
- abnormal corpus luteum morphology
- abnormal drinking behavior
- abnormal keratinocyte differentiation
- abnormal kidney morphology
- abnormal nociception after inflammation
- abnormal parturition
- abnormal response/metabolism to endogenous compounds
- abnormal small intestine crypts of Lieberkuhn morphology
- abnormal stomach pH
- abnormal thromboxane level
- abnormal urine homeostasis
- abnormal uterine environment
- abnormal wound healing
- allodynia
- altered response of heart to induced stress
- decreased digestive secretion
- decreased inflammatory response
- decreased physiological sensitivity to xenobiotic
- decreased platelet aggregation
- decreased prostaglandin level
- decreased susceptibility to induced arthritis
- decreased urine prostaglandin level
- delayed parturition
- enlarged spleen
- hypotonia
- increased bleeding time
- increased bronchoconstrictive response
- increased cellular sensitivity to gamma-irradiation
- increased circulating progesterone level
- increased mean systemic arterial blood pressure
- increased prostaglandin level
- increased renal glomerular filtration rate
- increased renal vascular resistance
- increased sensitivity to xenobiotic induced morbidity/mortality
- increased small intestinal crypt cell apoptosis
- increased susceptibility to endotoxin shock
- increased susceptibility to induced colitis
- increased susceptibility to injury
- increased thermal nociceptive threshold
- maternal effect
- perinatal lethality incomplete penetrance
role in cell
- apoptosis
- production in
- expression in
- activation in
- proliferation
- generation in
- induction in
- activation
- formation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- intracellular membrane-bounded organelle
- perinuclear region
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- inner nuclear membrane
- perinuclear space
- outer nuclear membrane
- nuclear envelope
- photoreceptor outer segments
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptgs1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- cyclooxygenase pathway
- prostaglandin biosynthetic process
- regulation of blood pressure
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- Golgi apparatus
- neuron projection
- photoreceptor outer segment
Molecular Function
What the gene product does at the molecular level
- peroxidase activity
- prostaglandin-endoperoxide synthase activity
- oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
- protein binding
- metal ion binding
- heme binding