EIF4G1 Gene Summary
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
Details
| Type | Protein Coding |
| Official Symbol | EIF4G1 |
| Official Name | eukaryotic translation initiation factor 4 gamma 1 [Source:HGNC Symbol;Acc:HGNC:3296] |
| Ensembl ID | ENSG00000114867 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 4 gamma 1 |
| Synonyms | E030015G23RIK,EIF4F,EIF4G,eIF-4-gamma 1,EIF4GI,eIF-4-γ 1,EUKARYOTIC protein SYNTHESIS INITIATION FACTOR,eukaryotic translation initiation factor 4 gamma 1,eukaryotic translation initiation factor 4, gamma 1,eukaryotic translation initiation factor 4 γ 1,eukaryotic translation initiation factor 4, γ 1,LOC100912571,LOC102550847,P220,PARK18 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding translation factor
- Family of unknown function (DUF5585)
- eIF4A binding domain
- mRNA binding
- MIF4G domain
- Eif3 binding domain
- ATP binding
- central domain
- Mnk1 binding domain
- protein binding
- eukaryotic initiation factor 4E binding
- translation regulator
- RNA binding
- MA3 domain
- PABP binding domain
- eIF4-gamma/eIF5/eIF2-epsilon
- translation initiation factor
- C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
- eIF4E binding domain
Pathways
Biological processes and signaling networks where the EIF4G1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease type 18
- chronic fatigue syndrome
- idiopathic inflammatory myopathy
- focal cortical dysplasia type I
role in cell
- differentiation
- growth
- expression in
- apoptosis
- survival
- cell death
- binding in
- autophagy by
- translation in
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic region
- ribosome
- Nucleus
- cytosol
- nucleoplasm
- stress granule
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the EIF4G1 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- negative regulation of translation involved in gene silencing by miRNA
- positive regulation of G1/S transition of mitotic cell cycle
- cap-dependent translational initiation
- neuron differentiation
- regulation of cellular response to stress
- positive regulation of neuron differentiation
- macromolecule biosynthetic process
- regulation of translational initiation
- translational initiation
- translation
- behavioral fear response
- response to ethanol
- positive regulation of protein metabolic process
- positive regulation of cell growth
- cellular response to nutrient levels
- negative regulation of peptidyl-threonine phosphorylation
- negative regulation of autophagy
- energy homeostasis
- lung development
- positive regulation of peptidyl-serine phosphorylation
cellular COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- eukaryotic translation initiation factor 4F complex
- cytoplasm
- membrane
- cytosol
- ribosome
molecular FUNCTION
What the gene product does at the molecular level
- ATP binding
- translation initiation factor activity
- protein binding
- RNA binding
- mRNA binding
- translation factor activity, nucleic acid binding
- translation initiation factor binding
- eukaryotic initiation factor 4E binding
- binding, bridging