TREM1 Gene Summary
This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Details
| Type | Protein Coding |
| Official Symbol | TREM1 |
| Official Name | triggering receptor expressed on myeloid cells 1 [Source:HGNC Symbol;Acc:HGNC:17760] |
| Ensembl ID | ENSG00000124731 |
| Bio databases IDs | |
| Aliases | triggering receptor expressed on myeloid cells 1 |
| Synonyms | AC241601.2,CD354,triggering receptor expressed on myeloid cells 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- protein binding
- loop domain
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the TREM1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sepsis
- periodontitis
- experimental keratitis
- pneumonia
- experimental colitis
- Crohn disease
- osteoarthritis
- diabetic nephropathy
- acute kidney injury
- septic shock
role in cell
- proliferation
- expression in
- phosphorylation in
- production in
- apoptosis
- activation in
- degranulation
- differentiation
- adhesion
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- azurophil granules
- specific granules
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TREM1 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- cytokine production involved in immune response
- innate immune response
- humoral immune response
- adaptive immune response
- neutrophil chemotaxis
- chemokine production
- neutrophil mediated killing of gram-negative bacterium
- intracellular signal transduction
cellular COMPONENT
Where in the cell the gene product is active
- extracellular region
- plasma membrane
- cell surface
molecular FUNCTION
What the gene product does at the molecular level
- scaffold protein binding
- transmembrane signaling receptor activity
- signaling receptor activity