Gatm Gene Summary [Mouse]
Predicted to enable glycine amidinotransferase activity. Involved in positive regulation of cold-induced thermogenesis. Located in mitochondrion. Is expressed in several structures, including extraembryonic component; foregut; genitourinary system; limb; and musculature. Human ortholog(s) of this gene implicated in AGAT deficiency and Fanconi renotubular syndrome 1. Orthologous to human GATM (glycine amidinotransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gatm |
| Official Name | glycine amidinotransferase (L-arginine:glycine amidinotransferase) [Source:MGI Symbol;Acc:MGI:1914342] |
| Ensembl ID | ENSMUSG00000027199 |
| Bio databases IDs | |
| Aliases | glycine amidinotransferase (L-arginine:glycine amidinotransferase) |
| Synonyms | 1810003P21Rik, AGAT, AT, CCDS3, FRTS, FRTS1, glycine amidinotransferase, glycine amidinotransferase (L-arginine:glycine amidinotransferase), L-arginine:Glycine Amidinotransferase, RFS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gatm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycine amidinotransferase
- amidinotransferase
- amidinotransferase-like
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- lymphoma
- diabetes mellitus
- lymphomagenesis
- renal failure
- renal clear cell adenocarcinoma
- renal clear cell cancer
- major depression
- arginine:glycine amidinotransferase deficiency
- Fanconi renotubular syndrome type 1
phenotypes
- abnormal behavior
- decreased circulating HDL cholesterol level
- decreased circulating alkaline phosphatase level
- decreased circulating cholesterol level
- decreased circulating insulin level
- decreased circulating phosphate level
- decreased circulating serum albumin level
- decreased circulating total protein level
- decreased circulating triglyceride level
- decreased circulating unsaturated transferrin level
- decreased grip strength
- decreased leukocyte cell number
- decreased mean platelet volume
- decreased red blood cell distribution width
- decreased startle reflex
- female infertility
- hypoactivity
- increased anxiety-related response
- increased circulating potassium level
- increased thigmotaxis
- male infertility
- thrombocytopenia
- abnormal circulating alkaline phosphatase level
- abnormal circulating potassium level
- abnormal circulating serum albumin level
- abnormal duodenum crypts of Lieberkuhn morphology
- abnormal eating behavior
- abnormal enterocyte proliferation
- abnormal gluconeogenesis
- abnormal glucose homeostasis
- abnormal grip strength
- abnormal locomotor activation
- abnormal prepulse inhibition
- abnormal red blood cell distribution width
- abnormal spermatogenesis
- abnormal testis morphology
- abnormal urine amino acid level
- decreased body length
- decreased body mass index
- decreased body weight
- decreased circulating glucose level
- decreased circulating leptin level
- decreased colon length
- decreased creatine level
- decreased liver triglyceride level
- decreased subcutaneous adipose tissue amount
- decreased susceptibility to diet-induced obesity
- decreased susceptibility to hepatic steatosis
- decreased total body fat amount
- decreased urine creatine level
- decreased urine creatinine level
- decreased white adipose tissue amount
- diarrhea
- hypotonia
- improved glucose tolerance
- increased adipocyte glucose uptake
- increased enterocyte apoptosis
- increased mean corpuscular volume
- increased muscle cell glucose uptake
- increased physiological sensitivity to xenobiotic
- increased pulmonary respiratory rate
- increased sensitivity to xenobiotic induced morbidity/mortality
- increased susceptibility to induced colitis
- increased susceptibility to weight loss
- scoliosis
role in cell
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial intermembrane space
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gatm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle atrophy
- creatine metabolic process
- creatine biosynthetic process
- learning or memory
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- extracellular vesicular exosome
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- glycine amidinotransferase activity
- protein binding
- amidinotransferase activity