Tnfaip1 Gene Summary [Mouse]
Predicted to enable cyclin binding activity; identical protein binding activity; and small GTPase binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including negative regulation of Rho protein signal transduction; positive regulation of DNA replication; and stress fiber assembly. Predicted to be located in endosome. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in brain; heart valve; peripheral nerve; sensory organ; and skeleton. Orthologous to human TNFAIP1 (TNF alpha induced protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfaip1 |
| Official Name | tumor necrosis factor, alpha-induced protein 1 (endothelial) [Source:MGI Symbol;Acc:MGI:104961] |
| Ensembl ID | ENSMUSG00000017615 |
| Bio databases IDs | |
| Aliases | tumor necrosis factor, alpha-induced protein 1 (endothelial) |
| Synonyms | B12, B61, Bacurd2, BTBD34, EDP1, hBACURD2, TNF alpha induced protein 1, Tnfip1, TNF α induced protein 1, tumor necrosis factor, alpha-induced protein 1 (endothelial), tumor necrosis factor, α-induced protein 1 (endothelial), tumour necrosis factor, alpha-induced protein 1 (endothelial), tumour necrosis factor, α-induced protein 1 (endothelial) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnfaip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- ubiquitin-protein transferase activity
- enzyme binding
- protein binding
- identical protein binding
- ion channel
- cyclin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- postoperative delirium
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
- osteoarthropathy
role in cell
- apoptosis
- production in
- formation
- K48 polyubiquitination in
- mitophagy in
- molecular cleavage in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- endosomes
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnfaip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of Rho protein signal transduction
- proteasomal ubiquitin-dependent protein catabolic process
- immune response
- apoptotic process
- protein homooligomerization
- positive regulation of DNA replication
- stress fiber assembly
- cell migration
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- endosome
- cytoplasm
- cytosol
- Cul3-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- identical protein binding
- protein binding
- small GTPase binding
- cyclin binding