Gatm Gene Summary [Rat]
Enables glycine amidinotransferase activity. Involved in several processes, including embryonic liver development; response to flavonoid; and response to mercury ion. Located in cytosol and mitochondrial inner membrane. Biomarker of acute kidney failure and kidney disease. Human ortholog(s) of this gene implicated in AGAT deficiency and Fanconi renotubular syndrome 1. Orthologous to human GATM (glycine amidinotransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gatm |
| Official Name | glycine amidinotransferase [Source:RGD Symbol;Acc:71090] |
| Ensembl ID | ENSRNOG00000000168 |
| Bio databases IDs | |
| Aliases | glycine amidinotransferase |
| Synonyms | 1810003P21Rik, AGAT, AT, CCDS3, FRTS, FRTS1, glycine amidinotransferase, glycine amidinotransferase (L-arginine:glycine amidinotransferase), L-arginine:Glycine Amidinotransferase, RFS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gatm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycine amidinotransferase
- amidinotransferase
- amidinotransferase-like
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- lymphoma
- diabetes mellitus
- lymphomagenesis
- renal failure
- renal clear cell adenocarcinoma
- renal clear cell cancer
- major depression
- arginine:glycine amidinotransferase deficiency
- Fanconi renotubular syndrome type 1
role in cell
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial intermembrane space
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gatm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle atrophy
- creatine metabolic process
- creatine biosynthetic process
- learning or memory
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- extracellular vesicular exosome
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- glycine amidinotransferase activity
- protein binding
- amidinotransferase activity