RNF7 Gene Summary [Human]
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RNF7 |
| Official Name | ring finger protein 7 [Source:HGNC Symbol;Acc:HGNC:10070] |
| Ensembl ID | ENSG00000114125 |
| Bio databases IDs | |
| Aliases | ring finger protein 7, sensitive to apoptosis zinc RING finger protein SAG, regulator of cullins 2, RING-box protein 2 |
| Synonyms | CKBBP1, Rbx2, ring finger protein 7, ROC2, SAG |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NEDD8 ligase
- copper ion binding
- zinc ion binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin protein ligase activity
- ubiquitin-like-protein ligase
- enzyme
- Ring finger domain
- protein binding
- RING-H2 zinc finger domain
- Anaphase-promoting complex subunit 11 RING-H2 finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- tumorigenesis
- breast cancer
- Alzheimer disease
- systemic lupus erythematosus
- colorectal cancer
- organismal death
role in cell
- phosphorylation in
- invasion by
- migration
- apoptosis
- accumulation in
- proliferation
- degradation in
- growth
- accumulation
- ribociclib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to redox state
- protein neddylation
- post-translational protein modification
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- Cul5-RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- copper ion binding
- NEDD8 ligase activity