Casp8ap2 Gene Summary [Mouse]
Enables cysteine-type endopeptidase activator activity involved in apoptotic process; identical protein binding activity; and protease binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in cytoplasm and nucleus. Predicted to be active in PML body and mitochondrion. Is expressed in several structures, including brain ventricular layer; incisor; inner cell mass; renal calyx; and submandibular gland primordium. Orthologous to human CASP8AP2 (caspase 8 associated protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Casp8ap2 |
| Official Name | caspase 8 associated protein 2 [Source:MGI Symbol;Acc:MGI:1349399] |
| Ensembl ID | ENSMUSG00000028282 |
| Bio databases IDs | |
| Aliases | caspase 8 associated protein 2 |
| Synonyms | caspase 8 associated protein 2, CED-4, D4Ertd659e, FLASH, RIP25 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Casp8ap2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- death receptor binding
- transcription regulator
- death effector domain-interacting domain
- protease binding
- NFkB activation domain
- transcription co-repressor
- Ced-4 homology domain
- apoptotic protease activator
- protein binding
- caspase activator
- identical protein binding
- DED recruiting domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometrial carcinoma
- epithelial endometrial cancer
- major depression
role in cell
- expression in
- molecular cleavage in
- activation in
- apoptosis
- biosynthesis in
- S phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- nuclear foci
- nucleoplasm
- Cajal bodies
- PML nuclear bodies
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Casp8ap2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to mechanical stimulus
- negative regulation of transcription, DNA-dependent
- signal transduction
- apoptotic signaling pathway
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- induction of apoptosis via death domain receptors
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- cytoplasm
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- apoptotic protease activator activity
- transcription corepressor activity
- SUMO polymer binding
- death receptor binding
- cysteine-type endopeptidase activator activity involved in apoptotic process