Nfe2l2 Gene Summary [Mouse]
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | Nfe2l2 |
| Official Name | nuclear factor, erythroid derived 2, like 2 [Source:MGI Symbol;Acc:MGI:108420] |
| Ensembl ID | ENSMUSG00000015839 |
| Bio databases IDs | |
| Aliases | nuclear factor, erythroid derived 2, like 2 |
| Synonyms | BM974200, HEBP1, IMDDHH, NFE2 like bZIP transcription factor 2, NRF2, nuclear factor, erythroid derived 2, like 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nfe2l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Neh4 domain
- transcription regulator
- protein binding activity, bridging
- transcription activation domain
- transcription factor binding
- coiled-coil domain
- leucine zipper domain
- Neh5 domain
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- ETGE motif
- MAP kinase site
- bZIP
- Neh6 domain
- ubiquitin protein ligase binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- DNA binding domain
- nucleic acid binding
- Basic region leucine zipper
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- DLG motif
- DNA binding
- Neh2 domain
- double-stranded DNA binding
- TRAM binding motif
- transcription factor activity
- basic region leucin zipper
- Keap1 binding domain
Pathways
Biological processes and signaling networks where the Nfe2l2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- metastasis
- squamous cell lung cancer
- gastric adenocarcinoma
- epithelial neoplasia
- epithelial cancer
- cancer
- liver neoplasia
- liver cancer
- digestive system cancer
phenotypes
- abnormal behavior
- abnormal enamel morphology
- abnormal erythrocyte physiology
- abnormal glomerular capillary morphology
- abnormal glomerular mesangium morphology
- abnormal incisor color
- abnormal iron homeostasis
- abnormal iron level
- abnormal leukocyte adhesion
- abnormal liver physiology
- abnormal macrophage physiology
- abnormal myelin sheath morphology
- abnormal neutrophil physiology
- abnormal periodontal ligament morphology
- abnormal physiological response to xenobiotic
- abnormal renal glomerulus morphology
- abnormal respiratory system physiology
- abnormal spleen physiology
- abnormal splenocyte physiology
- abnormal tooth morphology
- acanthocytosis
- alveolar process atrophy
- ameloblast degeneration
- anisocytosis
- astrocytosis
- cachexia
- circling
- decreased CD4-positive alpha beta T cell number
- decreased T cell number
- decreased body weight
- decreased catalase level
- decreased circulating interleukin-1 beta level
- decreased erythrocyte cell number
- decreased hematocrit
- decreased hemoglobin content
- decreased hepatocyte proliferation
- decreased liver regeneration
- decreased liver weight
- decreased urine creatinine level
- enlarged lung
- enlarged lymph nodes
- enlarged spleen
- glomerular crescent
- glomerulonephritis
- glomerulosclerosis
- hemolytic anemia
- hypoglycemia
- increased IgG level
- increased IgM level
- increased acute inflammation
- increased anti-double stranded DNA antibody level
- increased anti-nuclear antigen antibody level
- increased cellular sensitivity to hydrogen peroxide
- increased cerebral infarction size
- increased circulating alanine transaminase level
- increased circulating bilirubin level
- increased circulating interleukin-1 beta level
- increased circulating interleukin-6 level
- increased circulating tumor necrosis factor level
- increased fibroblast apoptosis
- increased hepatocyte apoptosis
- increased incidence of tumors by chemical induction
- increased kidney cell proliferation
- increased lactate dehydrogenase level
- increased liver iron level
- increased lung weight
- increased macrophage cell number
- increased number of Howell-Jolly bodies
- increased physiological sensitivity to xenobiotic
- increased sensitivity to xenobiotic induced morbidity/mortality
- increased spleen weight
- increased splenocyte apoptosis
- increased stomach tumor incidence
- increased susceptibility to experimental autoimmune uveoretinitis
- increased susceptibility to induced colitis
- increased susceptibility to ischemic brain injury
- increased urine protein level
- liver inflammation
- lung hemorrhage
- lung inflammation
- macrovesicular hepatic steatosis
- mesangial cell hyperplasia
- oxidative stress
- poikilocytosis
- premature death
- pulmonary fibrosis
- reticulocytosis
- schistocytosis
- spongiform encephalopathy
- thrombocytopenia
- weight loss
role in cell
- apoptosis
- cell viability
- survival
- killing
- migration
- expression in
- activation in
- phosphorylation in
- proliferation
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- organelle
- Cytoplasm
- Plasma Membrane
- basal bodies
- centrosome
- Golgi Apparatus
- cytosol
- caveolae
- nucleoplasm
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nfe2l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- positive regulation of blood coagulation
- negative regulation of cellular response to hypoxia
- positive regulation of transcription from RNA polymerase II promoter
- cellular response to copper ion
- positive regulation of angiogenesis
- regulation of cellular response to oxidative stress
- response to oxidative stress
- inflammatory response
- response to ischemia
- positive regulation of transcription, DNA-dependent
- cellular response to fluid shear stress
- endoplasmic reticulum unfolded protein response
- aflatoxin catabolic process
- cellular response to laminar fluid shear stress
- cellular response to tumor necrosis factor
- positive regulation of neuron projection development
- cellular response to hydrogen peroxide
- cellular response to hypoxia
- negative regulation of endothelial cell apoptotic process
- positive regulation of reactive oxygen species metabolic process
- proteasomal ubiquitin-independent protein catabolic process
- regulation of embryonic development
- positive regulation of glucose import
- cell redox homeostasis
- positive regulation of blood vessel endothelial cell migration
- cellular response to glucose starvation
- regulation of transcription from RNA polymerase II promoter
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of gene expression
- regulation of innate immune response
- cellular response to oxidative stress
- cellular response to xenobiotic stimulus
- negative regulation of cardiac muscle cell apoptotic process
- regulation of removal of superoxide radicals
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- mediator complex
- protein-DNA complex
- cytosol
- Golgi apparatus
- chromatin
- non-membrane-bounded organelle
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- transcription cofactor binding
- protein domain specific binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- ubiquitin protein ligase binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity