Crebbp Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription factor binding activity; TFIIB-class transcription factor binding activity; and disordered domain specific binding activity. Involved in several processes, including cellular response to virus; face morphogenesis; and regulation of gene expression. Acts upstream of or within cellular response to hepatocyte growth factor stimulus; germ-line stem cell population maintenance; and regulation of gene expression. Located in chromatin and nucleus. Part of RNA polymerase II transcription regulator complex; histone acetyltransferase complex; and outer kinetochore. Is expressed in several structures, including embryo ectoderm; eye; genitourinary system; heart; and skin. Used to study Rubinstein-Taybi syndrome; acute myeloid leukemia; autism spectrum disorder; and myelodysplastic syndrome. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crebbp |
| Official Name | CREB binding protein [Source:MGI Symbol;Acc:MGI:1098280] |
| Ensembl ID | ENSMUSG00000022521 |
| Bio databases IDs | |
| Aliases | CREB binding protein |
| Synonyms | AW558298, CBP, CBP/p300, CREB binding protein, KAT3A, MKHK1, p300/CBP, RSTS, RSTS1, RTS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crebbp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- protein interaction domain
- histone acetyltransferase domain
- SRC-1 interacting domain
- enhanceosome-interacting domain
- interferon-binding domain
- smad binding domain
- Histone acetylation protein
- transcription factor binding
- Bromodomain
- KIX domain
- glutamine-rich activation domain
- receptor binding domain
- acetyltransferase domain
- tau protein binding
- glutamine repeat domain
- RNA polymerase II holoenzyme binding domain
- p53-binding domain
- TAZ zinc finger
- ZZ
- activation domain
- histone acetyltransferase
- catalytic domain
- nucleic acid binding
- CR2 domain
- CH1 domain
- protein binding
- sequence-specific DNA binding
- c-Jun binding domain
- methylation site
- N-acetyltransferase
- PHD finger superfamily
- cysteine-histidine rich domain
- acetyltransferase
- Src binding domain
- CH3 domain
- transcription regulator
- cAMP response element binding protein binding
- LXXLL motif
- transcription co-activator
- transcription co-repressor
- RING_CBP-p300
- transcription activation domain
- chromatin binding
- Creb binding
- zinc bundle domain
- enzyme
- glutamine-rich domain
- SREBP binding domain
- nuclear receptor binding domain
- p160 binding domain
- peroxisome proliferator activated receptor binding
- zinc ion binding
- ID5
- TAZ1 domain
- Tax binding domain
- CREB binding domain
- N-acyltransferase
- CR1 domain
- alpha helix
- CR3 domain
- protein domain specific binding
- Ncoa1 binding domain
- p53 binding
- DNA binding
- binding protein
- damaged DNA binding
- double-stranded DNA binding
- adenovirus E1A binding domain
- polyglutamine repeat
- zinc finger domain
- CBP binding domain
- adenovirus 5 E1A-binding domain
- CAD domain
Pathways
Biological processes and signaling networks where the Crebbp gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- AMPK Signaling
- Androgen Signaling
- ATM Signaling
- Autophagy
- B Cell Receptor Signaling
- BMP signaling pathway
- Breast Cancer Regulation by Stathmin1
- Calcium Signaling
- Cardiac Hypertrophy Signaling
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- CREB Signaling in Neurons
- Dendritic Cell Maturation
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- ERK5 Signaling
- FGF Signaling
- Glucocorticoid Receptor Signaling
- Mouse Embryonic Stem Cell Pluripotency
- NF-κB Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- precursor B-cell acute lymphoblastic leukemia
- medulloblastoma
- cancer
- head and neck neoplasia
- neoplasia
- epithelial cancer
- advanced cancer
- metastasis
- limited-stage typical follicular lymphoma
- follicular non-Hodgkin disease
phenotypes
- abnormal blood vessel morphology
- abnormal cell differentiation
- abnormal common myeloid progenitor cell morphology
- abnormal craniofacial morphology
- abnormal definitive hematopoiesis
- abnormal embryonic growth/weight/body size
- abnormal extraembryonic tissue morphology
- abnormal forebrain morphology
- abnormal glucose homeostasis
- abnormal granulocyte morphology
- abnormal heart development
- abnormal heart morphology
- abnormal joint morphology
- abnormal leukocyte morphology
- abnormal limb morphology
- abnormal long term object recognition memory
- abnormal lung interstitium morphology
- abnormal megakaryocyte morphology
- abnormal mitral valve morphology
- abnormal nervous system morphology
- abnormal nest building behavior
- abnormal neural tube morphology
- abnormal occipital bone morphology
- abnormal pancreatic beta cell morphology
- abnormal pulmonary alveolus morphology
- abnormal rib morphology
- abnormal social investigation
- abnormal spinal cord morphology
- abnormal sternum morphology
- abnormal tumor necrosis factor level
- abnormal vascular development
- abnormal vascular endothelial cell development
- abnormal vasculogenesis
- abnormal vertebrae morphology
- absent organized vascular network
- absent pre-B cells
- absent vitelline blood vessels
- anemia
- atrial septal defect
- broad nasal bridge
- cleft secondary palate
- decreased B cell number
- decreased aggression towards males
- decreased angiogenesis
- decreased anxiety-related response
- decreased body size
- decreased body weight
- decreased circulating free fatty acid level
- decreased circulating glucagon level
- decreased common myeloid progenitor cell number
- decreased embryo size
- decreased fat cell size
- decreased grip strength
- decreased hematopoietic stem cell number
- decreased lymphocyte cell number
- decreased percent body fat/body weight
- decreased susceptibility to diet-induced obesity
- decreased thymocyte number
- decreased triglyceride level
- decreased vascular endothelial cell number
- decreased vertical activity
- decreased white adipose tissue amount
- delayed bone ossification
- embryonic growth arrest
- embryonic growth retardation
- embryonic lethality during organogenesis complete penetrance
- embryonic lethality during organogenesis incomplete penetrance
- embryonic lethality complete penetrance
- enlarged spleen
- exencephaly
- extramedullary hematopoiesis
- failure of vascular branching
- flattened snout
- hyperactivity
- hypoactivity
- impaired coordination
- impaired glucose tolerance
- impaired hematopoiesis
- improved glucose tolerance
- incomplete rostral neuropore closure
- increased bone marrow cell number
- increased cellular sensitivity to gamma-irradiation
- increased circulating adiponectin level
- increased circulating glucose level
- increased circulating insulin level
- increased circulating leptin level
- increased granulocyte number
- increased grooming behavior
- increased hemolymphoid system tumor incidence
- increased histiocytic sarcoma incidence
- increased insulin sensitivity
- increased leukemia incidence
- increased liver glycogen level
- increased megakaryocyte cell number
- increased oxygen consumption
- increased post-tetanic potentiation
- increased stereotypic behavior
- increased vertical activity
- insulin resistance
- intracranial hemorrhage
- large anterior fontanelle
- lethality throughout fetal growth and development incomplete penetrance
- maxilla hypoplasia
- nasal bone hypoplasia
- no abnormal phenotype detected
- oligodactyly
- open neural tube
- pale yolk sac
- pallor
- perimembraneous ventricular septal defect
- perinatal lethality incomplete penetrance
- postnatal growth retardation
- postnatal lethality
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- premature death
- prenatal lethality
- prenatal lethality incomplete penetrance
- preweaning lethality incomplete penetrance
- scoliosis
- seizures
- short maxilla
- short nasal bone
- short premaxilla
- short snout
- small lung
- split xiphoid process
- supernumerary teeth
- thin myocardium compact layer
- wide frontal bone
- xiphoid process foramen
role in cell
- expression in
- apoptosis
- upregulation in
- cell death
- proliferation
- production in
- activation in
- transactivation in
- transcription in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- aggregate
- Cytoplasm
- cytosol
- nuclear foci
- nucleoplasm
- nuclear bodies
- nuclear speckles
- Cajal bodies
- PML nuclear bodies
- kinetochores
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crebbp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein localization to nucleus
- macromolecular complex assembly
- signal transduction
- regulation of cellular response to heat
- regulation of transcription, DNA-dependent
- protein acetylation
- positive regulation of transcription from RNA polymerase II promoter
- I-kappaB kinase/NF-kappaB cascade
- stimulatory C-type lectin receptor signaling pathway
- embryonic digit morphogenesis
- regulation of smoothened signaling pathway
- protein destabilization
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- response to hypoxia
- cellular response to nutrient levels
- rhythmic process
- positive regulation of transcription, DNA-dependent
- homeostatic process
- N-terminal peptidyl-lysine acetylation
- cellular response to UV
- positive regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- nuclear body
- cytoplasm
- cytosol
- chromatin
- histone acetyltransferase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- zinc ion binding
- acetyltransferase activity
- histone acetyltransferase activity (H3-K18 specific)
- chromatin binding
- histone acetyltransferase activity (H3-K27 specific)
- damaged DNA binding
- MRF binding
- transcription coactivator binding
- histone acetyltransferase activity
- p53 binding
- protein binding
- transcription coactivator activity
- transcription corepressor activity
- peptide N-acetyltransferase activity