Lox Gene Summary [Mouse]
This gene encodes a precursor protein that belongs to the lysyl oxidase family of proteins. The secreted proprotein is proteolytically processed to an active mature peptide and a propeptide. This propeptide is thought to function in tumor suppression by inhibiting the Ras signaling pathway. The active enzyme plays a role in cross-linking of collagen and elastin and is essential for development of cardiovascular and respiratory systems, and development of skin and connective tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Details
| Type | Protein Coding |
| Official Symbol | Lox |
| Official Name | lysyl oxidase [Source:MGI Symbol;Acc:MGI:96817] |
| Ensembl ID | ENSMUSG00000024529 |
| Bio databases IDs | |
| Aliases | lysyl oxidase |
| Synonyms | AAT10, H-rev142, LYSINE OXIDASE, lysyl oxidase, rrg, Rrg1, Similar to lox, TSC-160 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lox often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytokine receptor homology domain
- copper ion binding
- binding protein
- catalytic domain
- protein-lysine 6-oxidase
- collagen binding
- enzyme
- protein binding
- Lysyl oxidase
- pro domain
Pathways
Biological processes and signaling networks where the Lox gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell cancer of the oral cavity
- oral squamous cell carcinoma
- metastasis
- neoplasia
- head and neck neoplasia
- gastrointestinal neoplasia
- Duchenne muscular dystrophy
- obesity
- organismal death
- bleeding
phenotypes
- abnormal craniofacial morphology
- abnormal placenta morphology
- abnormal placenta vasculature
- abnormal tail morphology
- increased heart weight
- preweaning lethality complete penetrance
- abnormal aorta elastic tissue morphology
- abnormal aorta smooth muscle morphology
- abnormal aorta wall morphology
- abnormal blood flow velocity
- abnormal blood vessel elastic tissue morphology
- abnormal blood vessel morphology
- abnormal bronchiole epithelium morphology
- abnormal cutaneous collagen fibril morphology
- abnormal cutaneous elastic fiber morphology
- abnormal descending thoracic aorta morphology
- abnormal diaphragm central tendon morphology
- abnormal diaphragm development
- abnormal diaphragm morphology
- abnormal enzyme/coenzyme activity
- abnormal pulmonary acinus morphology
- abnormal pulmonary artery morphology
- abnormal pulmonary elastic fiber morphology
- abnormal suckling behavior
- aorta stenosis
- aortic aneurysm
- atelectasis
- cyanosis
- decreased aorta elastin content
- decreased aorta wall thickness
- decreased lung weight
- decreased skin tensile strength
- decreased tumor latency
- diaphragmatic hernia
- dilated respiratory conducting tubes
- emphysema
- heart left ventricle hypertrophy
- heart right ventricle hypertrophy
- hemoperitoneum
- hemorrhage
- hemothorax
- hypoactivity
- impaired branching involved in respiratory bronchiole morphogenesis
- impaired branching involved in terminal bronchiole morphogenesis
- increased incidence of tumors by chemical induction
- increased lymphocyte cell number
- increased sensitivity to induced morbidity/mortality
- perinatal lethality complete penetrance
- pulmonary artery stenosis
- pulmonary hypoplasia
- semilunar valve regurgitation
- supravalvar aortic stenosis
role in cell
- apoptosis
- expression in
- activation in
- proliferation
- differentiation
- activation
- growth
- phosphorylation in
- migration
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- S-layer
- Nucleus
- cytoplasmic particles
- cytosol
- extracellular matrix
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lox gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- muscle cell homeostasis
- blood vessel morphogenesis
- response to xenobiotic stimulus
- cell chemotaxis
- heart development
- DNA biosynthetic process
- osteoblast differentiation
- peptidyl-lysine oxidation
- lung development
- bone mineralization
- platelet-derived growth factor receptor-beta signaling pathway
- muscle cell development
- regulation of megakaryocyte differentiation
- regulation of apoptotic process
- response to steroid hormone stimulus
- connective tissue development
- elastic fiber assembly
- regulation of protein phosphorylation
- ascending aorta development
- descending aorta development
- regulation of gene expression
- collagen fibril organization
- regulation of transforming growth factor beta receptor signaling pathway
- regulation of striated muscle tissue development
- negative regulation of protein kinase B signaling cascade
- regulation of platelet-derived growth factor receptor-beta signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- collagen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- copper ion binding
- collagen binding
- small molecule binding
- protein-lysine 6-oxidase activity
- binding, bridging