Adamts15 Gene Summary [Mouse]
This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active versicanase enzyme. This gene is located adjacent to a related ADAMTS gene (Adamts8) on chromosome 9. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | Adamts15 |
| Official Name | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15 [Source:MGI Symbol;Acc:MGI:2449569] |
| Ensembl ID | ENSMUSG00000033453 |
| Bio databases IDs | |
| Aliases | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15 |
| Synonyms | ADAM metallopeptidase with thrombospondin type 1 motif 15, ADAM metallopeptidase with thrombospondin type 1 motif, 15, DA12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adamts15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- Reprolysin family propeptide
- ADAMTS cysteine-rich domain 2
- extracellular matrix binding
- peptidase
- ADAM-TS Spacer 1
- ZnMc
- endopeptidase
- ADAM cysteine-rich
- Metallo-peptidase family M12B Reprolysin-like
- Reprolysin (M12B) family zinc metalloprotease
- furin cleavage site
- Spondin-like TSP1 domain
- pro domain
- heparin binding
Pathways
Biological processes and signaling networks where the Adamts15 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- distal arthrogryposis type 12
- distal arthrogryposis
- Hutchinson-Gilford progeria syndrome
- colorectal carcinomagenesis
- open-angle glaucoma
- survival
- severe preeclampsia
- colorectal carcinoma
- HER2 negative hormone receptor negative breast cancer
role in cell
- growth
- invasion by
- fusion
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adamts15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extracellular matrix disassembly
- proteolysis
- extracellular matrix organization
- myoblast fusion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix
- cell surface
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- zinc ion binding
- endopeptidase activity
- heparin binding
- metalloendopeptidase activity