Adamts15 Gene Summary [Rat]
Predicted to enable extracellular matrix binding activity; heparin binding activity; and metalloendopeptidase activity. Predicted to be involved in extracellular matrix disassembly; myoblast fusion; and proteolysis. Predicted to be located in cell surface and extracellular space. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in distal arthrogryposis. Orthologous to human ADAMTS15 (ADAM metallopeptidase with thrombospondin type 1 motif 15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adamts15 |
| Official Name | ADAM metallopeptidase with thrombospondin type 1 motif, 15 [Source:RGD Symbol;Acc:1309770] |
| Ensembl ID | ENSRNOG00000009892 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase with thrombospondin type 1 motif, 15 |
| Synonyms | ADAM metallopeptidase with thrombospondin type 1 motif 15, ADAM metallopeptidase with thrombospondin type 1 motif, 15, DA12 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adamts15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- Reprolysin family propeptide
- ADAMTS cysteine-rich domain 2
- extracellular matrix binding
- peptidase
- ADAM-TS Spacer 1
- ZnMc
- endopeptidase
- ADAM cysteine-rich
- Metallo-peptidase family M12B Reprolysin-like
- Reprolysin (M12B) family zinc metalloprotease
- furin cleavage site
- Spondin-like TSP1 domain
- pro domain
- heparin binding
Pathways
Biological processes and signaling networks where the Adamts15 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- distal arthrogryposis type 12
- distal arthrogryposis
- Hutchinson-Gilford progeria syndrome
- colorectal carcinomagenesis
- open-angle glaucoma
- survival
- severe preeclampsia
- colorectal carcinoma
- HER2 negative hormone receptor negative breast cancer
role in cell
- growth
- invasion by
- fusion
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adamts15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extracellular matrix disassembly
- proteolysis
- extracellular matrix organization
- myoblast fusion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix
- cell surface
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- zinc ion binding
- endopeptidase activity
- heparin binding
- metalloendopeptidase activity