St14 Gene Summary [Mouse]
Enables serine-type endopeptidase activity. Involved in proteolysis. Acts upstream of or within epithelial cell morphogenesis involved in placental branching and neural tube closure. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | St14 |
| Official Name | suppression of tumorigenicity 14 (colon carcinoma) [Source:MGI Symbol;Acc:MGI:1338881] |
| Ensembl ID | ENSMUSG00000031995 |
| Bio databases IDs | |
| Aliases | suppression of tumorigenicity 14 (colon carcinoma) |
| Synonyms | ARCI11, CAP3, Epithin, HAI, Matriptase, mCAP3, MT-SP1, PRSS14, SNC19, ST14 transmembrane serine protease matriptase, suppression of tumorigenicity 14 (colon carcinoma), suppression of tumourigenicity 14 (colon carcinoma), TADG15, TMPRSS14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse St14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- serine endopeptidase
- CUB
- trypsin
- Tryp_SPc
- serine-type peptidase
- ectodomain
- peptidase
- serine protease domain
- LDLa
- intracellular domain
- SEA domain
Pathways
Biological processes and signaling networks where the St14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- squamous cell cancer
- epithelial cancer
- epithelial neoplasia
- neoplasia
- dextran sodium sulfate-induced colitis
- lung cancer
- congenital ichthyosis, follicular atrophoderma, hypotrichosis and hypohidrosis
- ovarian cancer
- epidermal hyperplasia
phenotypes
- abnormal embryo size
- abnormal eye morphology
- abnormal forebrain morphology
- abnormal limb bud morphology
- abnormal liver size
- abnormal neural tube closure
- abnormal pericardium morphology
- abnormal placenta size
- prenatal lethality prior to heart atrial septation
- preweaning lethality complete penetrance
- abnormal corneocyte morphology
- abnormal epidermis stratum corneum morphology
- abnormal epidermis stratum granulosum morphology
- abnormal hair shaft morphology
- abnormal hard palate morphology
- abnormal keratinocyte differentiation
- abnormal piliary canal morphology
- abnormal skin appearance
- abnormal snout morphology
- abnormal stratum corneum lipid matrix formation
- abnormal tongue epithelium morphology
- abnormal vibrissa follicle morphology
- absent gastric milk in neonates
- absent vibrissae
- acanthosis
- alopecia
- decreased body length
- decreased body weight
- decreased double-positive T cell number
- decreased hair follicle number
- dehydration
- dry skin
- enlarged corneocyte envelope
- hyperkeratosis
- impaired skin barrier function
- impaired stratum corneum desquamation
- increased thymocyte apoptosis
- neonatal lethality complete penetrance
- postnatal lethality complete penetrance
- reddish skin
- scaly skin
- shiny skin
- thick epidermis
- underdeveloped hair follicles
- wrinkled skin
role in cell
- expression in
- activation in
- molecular cleavage in
- migration
- proliferation
- apoptosis
- phosphorylation in
- stabilization in
- formation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cell borders
- Extracellular Space
- cellular membrane
- plasma membrane extracellular face
- basolateral membrane
- junctional complexes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse St14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell morphogenesis involved in placental branching
- keratinocyte differentiation
- neural tube closure
- protein catabolic process
- proteolysis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- external side of plasma membrane
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase activity
- serine-type peptidase activity