Sema3f Gene Summary [Mouse]
Enables chemorepellent activity. Involved in several processes, including nervous system development; semaphorin-plexin signaling pathway; and ventral trunk neural crest cell migration. Acts upstream of or within several processes, including axon guidance; negative regulation of axon extension involved in axon guidance; and trunk neural crest cell migration. Located in extracellular space. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human SEMA3F (semaphorin 3F). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sema3f |
| Official Name | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F [Source:MGI Symbol;Acc:MGI:1096347] |
| Ensembl ID | ENSMUSG00000034684 |
| Bio databases IDs | |
| Aliases | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F |
| Synonyms | SEMA4, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F, SEMA-IV, SEMAK, SEMAPHORIN 3F, SEMAPHORIN III family HOMOLOG |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sema3f often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- Plexin repeat
- chemorepellant
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- Sema domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Sema3f gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- proliferative diabetic retinopathy
- hypogonadotropic hypogonadism
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- insomnia
- epithelial cancer
- cannabis dependence
- Alzheimer disease
role in cell
- migration
- morphology
- formation
- apoptosis
- activation in
- proliferation
- number
- invasion by
- growth
- retraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- Cytoplasm
- apical compartment
- cellular membrane
- cell-cell contacts
- apical cell surfaces
- membrane ruffles
- microfilaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sema3f gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative chemotaxis
- neural crest cell migration
- trigeminal nerve structural organization
- axon guidance
- negative regulation of axon extension involved in axon guidance
- facial nerve structural organization
- nerve development
- semaphorin-plexin signaling pathway
- axon extension involved in axon guidance
- branchiomotor neuron axon guidance
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- chemorepellent activity
- semaphorin receptor binding