NFYA Gene Summary [Human]
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NFYA |
| Official Name | nuclear transcription factor Y subunit alpha [Source:HGNC Symbol;Acc:HGNC:7804] |
| Ensembl ID | ENSG00000001167 |
| Bio databases IDs | |
| Aliases | nuclear transcription factor Y subunit alpha |
| Synonyms | CBF-A, CBF-B, FLJ11236, HAP2, LOC100129914, NFY, nuclear transcription factor-Y alpha, nuclear transcription factor Y subunit alpha, nuclear transcription factor Y subunit α, nuclear transcription factor-Y α, Nuclear transcription factor y, α, isoform 1, Nuclear transcription factor y, α, isoform 2, SEZ-10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NFYA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone-fold domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- DNA binding domain
- nucleic acid binding
- Pst domain
- transcription factor binding
- HAP2 domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
- double-stranded DNA binding
- heterodimerization domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the NFYA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- tumorigenesis
- organismal death
- acute myeloid leukemia
- gastric epithelial cancer
- allergic rhinitis
- hepatoid gastric adenocarcinoma
role in cell
- quantity
- growth
- migration
- expression in
- sphere formation
- apoptosis
- production in
- cell cycle progression
- differentiation
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NFYA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rhythmic process
- positive regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- CCAAT-binding factor complex
- protein-DNA complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity