ANKIB1 Gene Summary [Human]
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ANKIB1 |
| Official Name | ankyrin repeat and IBR domain containing 1 [Source:HGNC Symbol;Acc:HGNC:22215] |
| Ensembl ID | ENSG00000001629 |
| Bio databases IDs | |
| Aliases | ankyrin repeat and IBR domain containing 1 |
| Synonyms | 2310061P20Rik, 4631416I11Rik, ankyrin repeat and IBR domain containing 1, circAnkib1, KIAA1386, mKIAA1386 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ANKIB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- IBR domain, a half RING-finger domain
- zinc finger of C3HC4-type, RING
- Ankyrin repeats (3 copies)
- BRcat_Rcat_RBR
- Ring finger domain
- protein binding
- Ankyrin repeat
- In Between Ring fingers
- RING-type zinc-finger
- ubiquitin binding domain
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- breast carcinoma
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
regulated by
- NMS-873
- TCF7L2
role in cell
- expression in
- proliferation
- phosphorylation in
- JG-231 resistance
- regeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ANKIB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- ubiquitin ligase complex
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin conjugating enzyme binding
- zinc ion binding
- protein binding