ARRDC4 Gene Summary [Human]
Predicted to enable ubiquitin ligase-substrate adaptor activity. Acts upstream of or within positive regulation of ubiquitin-protein transferase activity. Located in endosome and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ARRDC4 |
| Official Name | arrestin domain containing 4 [Source:HGNC Symbol;Acc:HGNC:28087] |
| Ensembl ID | ENSG00000140450 |
| Bio databases IDs | |
| Aliases | arrestin domain containing 4 |
| Synonyms | 2410003C09RIK, Ab1-209, arrestin domain containing 4, AV216361, DRH1, LRRG00117 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARRDC4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Arrestin-related trafficking adapter 10 and similar proteins
- Arrestin (or S-antigen), C-terminal domain
- protein binding activity, bridging
- protein binding
- Arrestin (or S-antigen), N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- extracellular vesicles
- endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARRDC4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of ubiquitin-protein ligase activity
- positive regulation of interferon-beta production
- protein transport
- protein K63-linked ubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- early endosome
- endosome
- cytoplasm
- intracellular membrane-bounded organelle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding