SLC7A2 Gene Summary [Human]
The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | SLC7A2 |
| Official Name | solute carrier family 7 member 2 [Source:HGNC Symbol;Acc:HGNC:11060] |
| Ensembl ID | ENSG00000003989 |
| Bio databases IDs | |
| Aliases | solute carrier family 7 member 2 |
| Synonyms | 20.5, AI158848, ATRC2, CAT-2, Cat2a, Cat-2b, HCAT2, SLC7A2A, SLC7A2B, solute carrier family 7 (cationic amino acid transporter, y+ system), member 2, solute carrier family 7 member 2, Tea |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC7A2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- organic cation transporter
- amino acid permease (GABA permease)
- amino acid permease
- L-amino acid transporter
- L-type amino acid transporter
- basic amino acid transporter
- cationic amino acid transport permease
- C-terminus of AA_permease
- amino acid transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- rheumatoid arthritis
- neoplasia
- lung adenocarcinoma formation
- Alzheimer disease
- lung adenocarcinoma
- high-grade colon dysplasia
- cleft lip
role in cell
- expression in
- activation
- quantity
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC7A2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- amino acid transport
Cellular Component
Where in the cell the gene product is active
- cell junction
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- L-ornithine transmembrane transporter activity
- L-lysine transmembrane transporter activity
- basic amino acid transmembrane transporter activity
- amino acid transmembrane transporter activity