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Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Details
Type
Protein Coding
Official Symbol
RHOD
Official Name
ras homolog family member D [Source:HGNC Symbol;Acc:HGNC:670]
ras homolog family member D, Rho-related protein HP1, Rho-related GTP-binding protein RhoD
Synonyms
ARHD,ras homolog family member D,Rho,RHOHP1,RHOM
Species
Human, Homo sapiens
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
protein kinase binding
Small GTPase of the Ras superfamily (ill-defined subfamily)
Ras family
GTPase
enzyme
protein binding
Ras subfamily of RAS small GTPases
GTP binding
small GTP-binding protein domain
guanyl-nucleotide exchange factor
Rab subfamily of small GTPases
Ras of Complex, Roc, domain of DAPkinase
Rho (Ras homology) subfamily of Ras-like small GTPases
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
ERBB2
MYO18A
PICALM
TUBB2A
PPP2R1A
VAMP3
CANX
EMD
SPTB
VCP
disease
Alzheimer disease
major depression
non-insulin-dependent diabetes mellitus
hyperplasia
insomnia
keratocystic odontogenic tumor
keratocystic odontogenic tumors
Parkinson disease
regulated by
FGF2
TGFB1
ARHGAP5
TP63
CIP2A
C3-exoenzyme
FGF8
CSF1
BRAF
ERBB2
regulates
CDH5
PXN
actin
BCAR1
PTK2
PLXNA1
PIP5K1A
PIP5K1B
PIP5K1C
PDGFR
role in cell
cell death
migration
formation
morphology
adhesion
cell cycle progression
disassembly
cell spreading
invasion
assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
Cytoplasm
Plasma Membrane
endosomes
cytosol
Golgi membrane
mitochondrial outer membrane
endosomal membrane
recycling endosomes
early endosomes
cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the RHOD gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
regulation of actin cytoskeleton organization
signal transduction
regulation of small GTPase mediated signal transduction
lamellipodium assembly
actin filament organization
positive regulation of cell adhesion
Rho protein signal transduction
focal adhesion assembly
cell migration
actin filament bundle assembly
positive regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
early endosome
cytosol
endosome membrane
Golgi membrane
mitochondrial outer membrane
plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
GTP binding
protein kinase binding
GTPase activity
guanyl-nucleotide exchange factor activity
Gene-Specific Assays for Results You Can Trust
Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.