RHOD

RHOD Gene Summary

Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Details

Type
Protein Coding
Official Symbol
RHOD
Official Name
ras homolog family member D [Source:HGNC Symbol;Acc:HGNC:670]
Ensembl ID
ENSG00000173156
Bio databases IDs NCBI: 29984 Ensembl: ENSG00000173156
Aliases ras homolog family member D, Rho-related protein HP1, Rho-related GTP-binding protein RhoD
Synonyms
ARHD,ras homolog family member D,Rho,RHOHP1,RHOM
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein kinase binding
  • Small GTPase of the Ras superfamily (ill-defined subfamily)
  • Ras family
  • GTPase
  • enzyme
  • protein binding
  • Ras subfamily of RAS small GTPases
  • GTP binding
  • small GTP-binding protein domain
  • guanyl-nucleotide exchange factor
  • Rab subfamily of small GTPases
  • Ras of Complex, Roc, domain of DAPkinase
  • Rho (Ras homology) subfamily of Ras-like small GTPases
  • P-loop containing Nucleoside Triphosphate Hydrolases

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • ERBB2
  • MYO18A
  • PICALM
  • TUBB2A
  • PPP2R1A
  • VAMP3
  • CANX
  • EMD
  • SPTB
  • VCP
disease
  • Alzheimer disease
  • major depression
  • non-insulin-dependent diabetes mellitus
  • hyperplasia
  • insomnia
  • keratocystic odontogenic tumor
  • keratocystic odontogenic tumors
  • Parkinson disease
regulated by
  • FGF2
  • TGFB1
  • ARHGAP5
  • TP63
  • CIP2A
  • C3-exoenzyme
  • FGF8
  • CSF1
  • BRAF
  • ERBB2
regulates
  • CDH5
  • PXN
  • actin
  • BCAR1
  • PTK2
  • PLXNA1
  • PIP5K1A
  • PIP5K1B
  • PIP5K1C
  • PDGFR
role in cell
  • cell death
  • migration
  • formation
  • morphology
  • adhesion
  • cell cycle progression
  • disassembly
  • cell spreading
  • invasion
  • assembly

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Plasma Membrane
  • endosomes
  • cytosol
  • Golgi membrane
  • mitochondrial outer membrane
  • endosomal membrane
  • recycling endosomes
  • early endosomes
  • cellular protrusions

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the RHOD gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • regulation of actin cytoskeleton organization
  • signal transduction
  • regulation of small GTPase mediated signal transduction
  • lamellipodium assembly
  • actin filament organization
  • positive regulation of cell adhesion
  • Rho protein signal transduction
  • focal adhesion assembly
  • cell migration
  • actin filament bundle assembly
  • positive regulation of cell migration

CELLULAR COMPONENT

Where in the cell the gene product is active
  • early endosome
  • cytosol
  • endosome membrane
  • Golgi membrane
  • mitochondrial outer membrane
  • plasma membrane

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • GTP binding
  • protein kinase binding
  • GTPase activity
  • guanyl-nucleotide exchange factor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.