RPAP3 Gene Summary [Human]
This gene encodes an RNA polymerase II-associated protein. The encoded protein may function in transcriptional regulation and may also regulate apoptosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Details
| Type | Protein Coding |
| Official Symbol | RPAP3 |
| Official Name | RNA polymerase II associated protein 3 [Source:HGNC Symbol;Acc:HGNC:26151] |
| Ensembl ID | ENSG00000005175 |
| Bio databases IDs | |
| Aliases | RNA polymerase II associated protein 3 |
| Synonyms | 2310042P20Rik, D15Ertd682e, hSpagh, MSPAGHETTI, RNA polymerase II associated protein 3, Spagh, Tah1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPAP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR repeat
- Tetratricopeptide repeats
- enzyme
- protein binding
- tetratricopeptide repeat
- Potential Monad-binding region of RPAP3
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- basal bodies
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RPAP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- R2TP complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding