ALDH3B2 Gene Summary [Human]
This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. Altered methylation patterns at this locus have been observed in spermatozoa derived from patients exhibiting reduced fecundity. [provided by RefSeq, Aug 2017]
Details
| Type | Protein Coding |
| Official Symbol | ALDH3B2 |
| Official Name | aldehyde dehydrogenase 3 family member B2 [Source:HGNC Symbol;Acc:HGNC:411] |
| Ensembl ID | ENSG00000132746 |
| Bio databases IDs | |
| Aliases | aldehyde dehydrogenase 3 family member B2, aldehyde dehydrogenase 8, acetaldehyde dehydrogenase 8 |
| Synonyms | aldehyde dehydrogenase 3 family member B2, ALDH8 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ALDH3B2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- aldehyde dehydrogenase [NAD(P)]
- aldehyde dehydrogenase
- enzyme
- protein binding
- NAD(P)+-dependent aldehyde dehydrogenase superfamily
Pathways
Biological processes and signaling networks where the ALDH3B2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lipid droplets
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ALDH3B2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular aldehyde metabolic process
- lipid metabolic process
- ethanol catabolic process
- alcohol metabolic process
- sphingolipid catabolic process
Cellular Component
Where in the cell the gene product is active
- lipid particle
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- aldehyde dehydrogenase (NAD) activity
- 3-chloroallyl aldehyde dehydrogenase activity
- glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
- aldehyde dehydrogenase [NAD(P)+] activity