Ccl26 Gene Summary [Mouse]
Predicted to enable CCR3 chemokine receptor binding activity; CX3C chemokine receptor binding activity; and chemokine activity. Predicted to be involved in several processes, including leukocyte chemotaxis; positive regulation of GTPase activity; and positive regulation of actin filament polymerization. Predicted to be active in extracellular space. Is expressed in several structures, including aorta; bone marrow; brain; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in asthma; eosinophilic esophagitis; and rhinitis. Orthologous to human CCL26 (C-C motif chemokine ligand 26). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccl26 |
| Official Name | chemokine (C-C motif) ligand 26 [Source:MGI Symbol;Acc:MGI:3589281] |
| Ensembl ID | ENSMUSG00000070464 |
| Bio databases IDs | |
| Aliases | chemokine (C-C motif) ligand 26 |
| Synonyms | Ccl26l, C-C motif chemokine ligand 26, IMAC, LOC687177, MIP-4a, MIP-4alpha, SCYA26, TSC-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccl26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- chemokine receptor binding
- receptor agonist activity
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the Ccl26 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Crohn disease
- eosinophilic esophagitis
- mastocytosis
- COVID-19
- peroxisomal acyl CoA oxidase deficiency
- angioimmunoblastic T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- pruritus
- ulcerative colitis
role in cell
- binding
- activation in
- proliferation
- migration
- activation
- recruitment
- chemotaxis
- polymerization
- shape change
- healing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Weibel-Palade bodies
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccl26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- cell-cell signaling
- positive regulation of GTPase activity
- chemotaxis
- inflammatory response
- T cell chemotaxis
- monocyte chemotaxis
- chemokine-mediated signaling pathway
- eosinophil chemotaxis
- positive regulation of actin filament polymerization
- positive regulation of endothelial cell proliferation
- positive regulation of chemotaxis
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- CX3C chemokine receptor binding
- CCR chemokine receptor binding
- protein binding
- CCR3 chemokine receptor binding
- receptor agonist activity
- chemokine activity