DBF4 Gene Summary [Human]
Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in positive regulation of nuclear cell cycle DNA replication and regulation of cell cycle phase transition. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | DBF4 |
| Official Name | DBF4 zinc finger [Source:HGNC Symbol;Acc:HGNC:17364] |
| Ensembl ID | ENSG00000006634 |
| Bio databases IDs | |
| Aliases | DBF4 zinc finger, activator of S phase kinase, chiffon homolog (Drosophila), zinc finger, DBF-type containing 1, DBF4 zinc finger A |
| Synonyms | ASK, CHIF, DBF4A, DBF4-CDC7 kinase regulatory subunit, DBF4 zinc finger, LOC100912278, LOC103690019, RGD1305854, ZDBF1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DBF4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Zinc finger in DBF-like proteins
- protein serine/threonine kinase
- BRCT
- Dbf4-motif-M
- BRCA1 C Terminus (BRCT) domain
- Dbf4-motif-C
- protein binding
- DBF zinc finger
- enzyme activator activity
- proline rich domain
Pathways
Biological processes and signaling networks where the DBF4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
- lymphomagenesis
- B cell cancer
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- urothelial bladder carcinoma
- transitional cell bladder cancer
- lung squamous cell carcinoma
role in cell
- proliferation
- cell cycle progression
- migration
- adhesion
- protection
- rearrangement in
- S phase checkpoint control in
- G1/S phase transition
- re-replication in
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DBF4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA replication involved in S phase
- DNA replication
- G1/S transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nuclear body
- Dbf4-dependent protein kinase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- zinc ion binding
- protein binding
- protein serine/threonine kinase activator activity
- enzyme activator activity