Dbf4 Gene Summary [Mouse]
Predicted to enable protein serine/threonine kinase activator activity and protein serine/threonine kinase activity. Predicted to be involved in positive regulation of nuclear cell cycle DNA replication and regulation of cell cycle phase transition. Predicted to act upstream of or within traversing start control point of mitotic cell cycle. Located in nucleus. Is expressed in several structures, including brain ventricular layer; early conceptus; genitourinary system; and gut. Orthologous to human DBF4 (DBF4-CDC7 kinase regulatory subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dbf4 |
| Official Name | DBF4 zinc finger [Source:MGI Symbol;Acc:MGI:1351328] |
| Ensembl ID | ENSMUSG00000002297 |
| Bio databases IDs | |
| Aliases | DBF4 zinc finger |
| Synonyms | ASK, CHIF, DBF4A, DBF4-CDC7 kinase regulatory subunit, DBF4 zinc finger, LOC100912278, LOC103690019, RGD1305854, ZDBF1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dbf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Zinc finger in DBF-like proteins
- protein serine/threonine kinase
- BRCT
- Dbf4-motif-M
- BRCA1 C Terminus (BRCT) domain
- Dbf4-motif-C
- protein binding
- DBF zinc finger
- enzyme activator activity
- proline rich domain
Pathways
Biological processes and signaling networks where the Dbf4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
- lymphomagenesis
- B cell cancer
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- urothelial bladder carcinoma
- transitional cell bladder cancer
- lung squamous cell carcinoma
role in cell
- proliferation
- cell cycle progression
- migration
- adhesion
- protection
- rearrangement in
- S phase checkpoint control in
- G1/S phase transition
- re-replication in
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dbf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA replication involved in S phase
- DNA replication
- G1/S transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nuclear body
- Dbf4-dependent protein kinase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- zinc ion binding
- protein binding
- protein serine/threonine kinase activator activity
- enzyme activator activity