MYH13 Gene Summary [Human]
Predicted to enable microfilament motor activity. Predicted to be involved in muscle contraction. Predicted to act upstream of or within cellular response to starvation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MYH13 |
| Official Name | myosin heavy chain 13 [Source:HGNC Symbol;Acc:HGNC:7571] |
| Ensembl ID | ENSG00000006788 |
| Bio databases IDs | |
| Aliases | myosin heavy chain 13, extraocular muscle myosin heavy chain, extraocular myosin heavy chain |
| Synonyms | MHCEO, MyHC, MyHC-eo, MyHC-IIL, myosin heavy chain 13, myosin, heavy polypeptide 13, skeletal muscle |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MYH13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- Crescentin protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Weak chloroplast movement under blue light
- Myosin and Kinesin motor domain
- rad50
- Synaptonemal complex protein 1 (SCP-1)
- microfilament motor protein
- Myosin N-terminal SH3-like domain
- Myosin tail
- helix-rich Mycoplasma protein
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Laminin Domain I
- Myosin head (motor domain)
- Alpha helical coiled-coil rod protein (HCR)
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- Mechanosensitive ion channel porin domain
- RIM-binding protein of the cytomatrix active zone
- Intermediate filament protein
- Septation ring formation regulator, EzrA
- Myosin
- HOOK protein coiled-coil region
Pathways
Biological processes and signaling networks where the MYH13 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myofibrils
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MYH13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle contraction
- cellular response to starvation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- muscle myosin complex
- cytoplasm
- myosin II complex
- myosin filament
- myofibril
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- calmodulin binding
- microfilament motor activity